TIGIT 抗体 (AA 22-141)
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- 抗原 See all TIGIT 抗体
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
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抗原表位
- AA 22-141
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TIGIT antibody is un-conjugated
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应用范围
- ELISA, Flow Cytometry (FACS), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR), causing increased IL10 secretion, decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells, as well as peripheral memory and regulatory CD4+ T cells. At the protein level, it is upregulated following the activation of these cells. Functionally, TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is an immuno-oncology target for therapy.
- 交叉反应 （详细）
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant fragment (around aa 22-141) of human TIGIT protein (exact sequence is proprietary)
- 克隆位点
- TIGIT-3017
- 亚型
- IgG2c kappa
- Top Product
- Discover our top product TIGIT Primary Antibody
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anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 21-234) antibody
TIGIT 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 ELISA, IHC, FACS, Coat, StM 宿主: 小鼠 Monoclonal TIGIT-3017 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 WB, ELISA, IHC, ICC, FACS, Neut 宿主: 小鼠 Monoclonal 4C5B9 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 28-246) antibodyTIGIT 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 ELISA, IHC, Coat, StM 宿主: 小鼠 Monoclonal TIGIT-3106 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 28-227) antibodyTIGIT 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) antibodyTIGIT 适用: 小鼠 ELISA, FACS, BP 宿主: 兔 Chimeric 1B4 unconjugated Recombinant Antibody
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 12-142) antibodyTIGIT 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB55818 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) antibodyTIGIT 适用: 小鼠 FACS, Agon 宿主: 兔 Chimeric 4D4 unconjugated Recombinant Antibody
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- 应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), Flow Cytometry (1-2 μg/million cells),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: MOLT-4, Prostate or Colon Carcinoma.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
- 别名
- TIGIT (TIGIT 产品)
- 别名
- VSIG9 antibody, VSTM3 antibody, WUCAM antibody, ENSMUSG00000071552 antibody, Vstm3 antibody, RGD1563191 antibody, T-cell immunoreceptor with Ig and ITIM domains antibody, T cell immunoreceptor with Ig and ITIM domains antibody, TIGIT antibody, Tigit antibody
- 背景
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T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain containing 9 (VSIG9), V-set and transmembrane domain containing 3 (VSTM3), Washington University cell adhesion molecule (WUCAM),TIGIT / VSTM3 / VSIG9 (Immune Checkpoint for Cancer)
Cellular localisation: Cell Surface - 分子量
- 26kDa
- 基因ID
- 201633, 421750
- 途径
- Cancer Immune Checkpoints
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