Gelsolin 抗体
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- 抗原 See all Gelsolin (GSN) 抗体
- Gelsolin (GSN)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Gelsolin antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
- 交叉反应 （详细）
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant human full-length protein
- 克隆位点
- CPTC-Gelsolin-1
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product GSN Primary Antibody
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anti-Gelsolin (GSN) (AA 170-423) antibody
GSN 适用: Cow WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Gelsolin (GSN) (AA 674-782) antibodyGSN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gelsolin (GSN) (AA 577-771) antibodyGSN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gelsolin (GSN) (AA 673-782) antibodyGSN 适用: 人 WB, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 3G5 unconjugated
anti-Gelsolin (GSN) (AA 543-782) antibodyGSN 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gelsolin (GSN) antibodyGSN 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5E3B9 unconjugated
anti-Gelsolin (GSN) (AA 432-553) antibodyGSN 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Gelsolin (GSN) (AA 432-625) antibodyGSN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gelsolin (GSN) (AA 1-782) antibodyGSN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Gelsolin (GSN) (C-Term) antibodyKO Validated GSN 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Known_Application: Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: MCF cell lysate, Tonsil.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- Gelsolin (GSN)
- 别名
- GSN (GSN 产品)
- 别名
- ADF antibody, AGEL antibody, CG1106 antibody, DGS antibody, Dmel\\CG1106 antibody, gel antibody, scin antibody, cb107 antibody, gsn antibody, sb:cb107 antibody, u-gelsolin antibody, wu:fi16f06 antibody, gelsolin antibody, Gelsolin antibody, gelsolin S homeolog antibody, gelsolin a antibody, GSN antibody, Gel antibody, Gsn antibody, gsn.S antibody, gsn antibody, gsna antibody
- 背景
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Actin depolymerizing factor, ADF, AGEL, Brevin, Gsn,Gelsolin / Actin-depolymerizing Factor
Cellular localisation: Cytoplasm and secreted - 分子量
- 90kDa
- 基因ID
- 2934, 522373
- UniProt
- P06396
- 途径
- Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy
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