CASP5 抗体
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- 抗原 See all CASP5 抗体
- CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CASP5 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 原理
- Rabbit Anti-Human CASP5
- 特异性
- DS-PB-00380 recognizes an epitope located within the internal region of human Caspase5, a 47kDa cysteine protease, otherwise known as ICH3. Caspase5 has been shown to be expressed at higher levels in the colon, lung, spleen, small intestine and by peripheral blood lymphocytes. Caspase5 is a member of a growing number of inflammatory caspases belonging to the Caspase1 (ICEtype) subfamily, which require proteolytic processing of their inactive precursor into smaller active subunits. Unlike Caspase1, Caspase5 is not directly responsible for the activation of IL1Beta from the proIL1Beta precursor, but the presence of Caspase5 does appear to enhance the processing of IL1Beta. The in vivo expression of Caspase5 is elevated by Lipopolysaccharide (LPS) and gene expression is also increased by Interferon gamma (IFNg). In vitro studies have shown cleavage of Caspase5 by the serine protease Granzyme B, which plays a major role in Cytotoxic T lymphocyte (CTL)induced apoptosis (1).
- 产品特性
- Phosphorylation/Apoptosis/Signal Transduction/Regulation
- 纯化方法
- Purified
- 免疫原
- Antisera to human Caspase-5 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- 亚型
- IgG
- Top Product
- Discover our top product CASP5 Primary Antibody
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anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) (AA 145-327) antibody
CASP5 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) (AA 162-191) antibodyCASP5 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) (AA 162-191) antibodyCASP5 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18988 unconjugated
anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) antibodyCASP5 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) antibodyCASP5 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) (AA 146-175), (Middle Region) antibodyCASP5 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) (Cleaved-Ser331) antibodyCASP5 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) (Cleaved-Asp121) antibodyCASP5 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) (AA 251-300) antibodyCASP5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) (Middle Region) antibodyCASP5 适用: 人, Cow, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Western Blotting
- 限制
- 仅限研究用
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- 浓度
- IgG concentration 1.0 mg/ml
- 缓冲液
- Phosphate buffered saline
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C
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- 抗原
- CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
- 别名
- Caspase-5 (CASP5 产品)
- 别名
- ICE(rel)III antibody, ICEREL-III antibody, ICH-3 antibody, CASP5 antibody, caspase 5 antibody, caspase-5 antibody, CASP5 antibody, LOC100437308 antibody
- 途径
- Inflammasome
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