CASP5 抗体 (AA 162-191)
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Quick Overview for CASP5 抗体 (AA 162-191) (ABIN3030309)
抗原
See all CASP5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 162-191
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 162-191 from the human protein was used as the immunogen for this Caspase-5 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the Caspase-5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Caspase-5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
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别名
- Caspase-5
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背景
- This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
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UniProt
- P51878
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途径
- Inflammasome
抗原
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