TRAIL 抗体
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- 抗原 See all TRAIL (TNFSF10) 抗体
- TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TRAIL antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- Rabbit Anti-Human CD253
- 特异性
- DS-PB-02541 is specific for human CD253, otherwise known as TRAIL or Apo2L, a 281 amino acid type II transmembrane glycoprotein and member of the tumor necrosis factor superfamily, which induces apoptosis in tumor and transformed cells, but not normal cells. Activation of apoptosis by CD253 occurs through binding to the death-signaling receptors DR4 (TRAILR1) and DR5 (TRAILR2), leading to formation of the death-inducing signaling complex (DISC) and the triggering of a proteolytic caspase cascade. There are however decoy receptors known as DcR1 (TRAILR3) and DcR2 (TRAILR4) which competitively bind to CD253 and are unable to initiate apoptosis. CD253 also plays a role in immune surveillance, acting as a mediator of monocyte, NK cell, dendritic cell and T cell anti-tumor and anti-viral cytotoxicity.
- 产品特性
- Adhesion Molecule/Cell Surface
- 纯化方法
- Purified
- 免疫原
- Antisera to human CD253 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
- 亚型
- IgG
- Top Product
- Discover our top product TNFSF10 Primary Antibody
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anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 39-250) antibody
TNFSF10 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 185-281) antibodyTNFSF10 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 95-281) antibodyTNFSF10 适用: 人 FACS, Func 宿主: 小鼠 Monoclonal 2E5 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 95-281) antibody (PE)TNFSF10 适用: 人 FACS 宿主: 小鼠 Monoclonal 2E5 PE
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 115-287) antibodyTNFSF10 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 95-281) antibodyTNFSF10 适用: 人 WB, FACS, ICC, IHC (f) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 1-300) antibodyTNFSF10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) antibodyTNFSF10 适用: 人 WB, ELISA, IHC, IHC (p), Neut 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 1-300) antibodyTNFSF10 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (Internal Region) antibodyTNFSF10 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- ELISA (dilution: 0.1, 0.2 μg/mL), Immunohistology - Paraffin, Western Blotting
- 限制
- 仅限研究用
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- 溶解方式
- Reconstitute with 0.1 mL distilled water. For long term storage the addition of 0.09 % sodium azide is recommended.
- 浓度
- IgG concentration 1.0 mg/ml after reconstitution
- 缓冲液
- Phosphate buffered saline pH7.4
- 储存条件
- -20 °C
- 储存方法
- -20°C
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- 抗原
- TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
- 别名
- CD253 (TNFSF10 产品)
- 别名
- APO2L antibody, Apo-2L antibody, CD253 antibody, TL2 antibody, TRAIL antibody, A330042I21Rik antibody, AI448571 antibody, APO-2L antibody, Ly81 antibody, Trail antibody, tl2 antibody, apo2l antibody, cd253 antibody, trail antibody, apo-2l antibody, trail1 antibody, xtrail1 antibody, tnfsf10l2 antibody, zgc:92320 antibody, TNLG6A antibody, TNF superfamily member 10 antibody, tumor necrosis factor (ligand) superfamily, member 10 antibody, tumor necrosis factor superfamily member 10 antibody, TNF superfamily member 10 S homeolog antibody, TNFSF10 antibody, Tnfsf10 antibody, tnfsf10.S antibody, tnfsf10 antibody
- 途径
- Apoptosis, Positive Regulation of Endopeptidase Activity
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