APPL2 抗体
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- 抗原 See all APPL2 抗体
- APPL2 (Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
- 适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This APPL2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human APPL2
- 亚型
- IgG
- Top Product
- Discover our top product APPL2 Primary Antibody
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- 应用备注
- WB 1:500 - 1:2000
- 说明
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High levels in brain, heart, kidney and skeletal muscle
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20C. Avoid freeze / thaw cycles.
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- 抗原
- APPL2 (Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
- 别名
- APPL2 (APPL2 产品)
- 别名
- RGD1563028 antibody, MGC84621 antibody, dip13b antibody, APPL2 antibody, DIP13B antibody, Dip3b antibody, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 antibody, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog antibody, adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 antibody, Appl2 antibody, APPL2 antibody, appl2.L antibody, appl2 antibody
- 背景
- The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12,22)(q24.1,q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.
- 分子量
- 74.493 kDa
- 基因ID
- 55198
- UniProt
- Q8NEU8
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