APPL2 产品
(Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
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The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011].
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Featured APPL2 Categories
Recommended APPL2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (3)
Cat. No.
ABIN527414
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN527415
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF, IHC
Validations
- (2)
Cat. No.
ABIN7149505
Quantity
100 μg
Datasheet
Datasheet
Recommended APPL2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964611
Quantity
96 tests
Datasheet
Datasheet
Recommended APPL2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121696
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345410
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345412
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our APPL2 Products
: "Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice." in: The European journal of neuroscience, (2019) (PubMed).: "The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle." in: Life sciences, Vol. 210, pp. 209-213, (2018) (PubMed).
: "Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice." in: Cytokine, Vol. 110, pp. 87-93, (2018) (PubMed).
: "The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway." in: The Journal of endocrinology, Vol. 210, Issue 1, pp. 81-92, (2011) (PubMed).
Synonyms and alternative names related to APPL2
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2), APPL2, Dip3b, dip13b, DIP13B, MGC84621, RGD1563028Protein level used designations for APPL2
- DCC-interacting protein 13-beta
- adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- amyloid beta (A4) precursor-like protein 2
- DIP13 beta
- adapter protein containing PH domain, PTB domain and leucine zipper motif 2
- Dip3 beta
- dip13-beta
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