JAK3 抗体 (AA 720-800)
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- 抗原 See all JAK3 抗体
- JAK3 (Janus Kinase 3 (JAK3))
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抗原表位
- AA 720-800
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This JAK3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- JAK3 is a protein encoded by the JAK3 gene which is approximately 125 kDa. JAK3 is localised to the endomembrane system. It is involved in RET signalling, common cytokine receptor gamma-chain family signalling pathways, Th17 cell differentiation and the IL-2 pathway. It is a non-receptor tyrosine kinase involved in various processes such as cell growth, development and differentiation. It mediates essential signalling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm it also plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R and IL7R. JAK3 is only expressed in NK cells and NK-like cell lines. Mutations in the JAK3 gene may result in severe combined immunodeficiency and Janus kinase-3 deficiency. STJ93795 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of JAK3 protein.
- 特异性
- JAK3 Polyclonal Antibody detects endogenous levels of JAK3 protein.
- 产品特性
- Rabbit polyclonal to JAK3.
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from human JAK3 around the non-phosphorylation site of Y785.
- 亚型
- IgG
- Top Product
- Discover our top product JAK3 Primary Antibody
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- 应用备注
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WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000 - 说明
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In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- 抗原
- JAK3 (Janus Kinase 3 (JAK3))
- 别名
- JAK3 (JAK3 产品)
- 别名
- JAK-3 antibody, JAK3_HUMAN antibody, JAKL antibody, L-JAK antibody, LJAK antibody, fae antibody, wil antibody, RATJAK3 antibody, JAK antibody, Janus kinase 3 antibody, JAK3 antibody, Jak3 antibody
- 分子量
- 125 kDa
- 基因ID
- 3718
- UniProt
- P52333
- 途径
- JAK/STAT Signaling, RTK signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response
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