ERK 1/2 is a protein encoded by the MAPK1 gene which is approximately 41,4 kDa. ERK 1/2 is localised to the cytoplasm and nucleus. It is involved in RET signalling, activated TLR4 signalling, IL-2 pathway, regulation of lipid metabolism and insulin signalling-generic cascades. This protein falls under the MAP kinase family. It is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. It also acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. ERK 1/2 is expressed in the nervous system, blood, lung, liver and skin. Mutations in the MAPK1 gene may result in small intestine neuroendocrine neoplasm and pertussis. STJ90261 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous ERK 1/2 protein which only binds about Y204 when Y204 is phosphorylated.
特异性
Phospho-ERK 1/2 (Y204) Polyclonal Antibody detects endogenous levels of ERK 1/2 protein only when phosphorylated at Y204.
产品特性
Rabbit polyclonal to Phospho-ERK 1/2 (Y204).
纯化方法
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
免疫原
Synthesized peptide derived from human ERK 1/2 around the phosphorylation site of Y204.