IKK-alpha /IKK-beta 抗体 (pSer176, pSer177)
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- 抗原 See all IKK-alpha /IKK-beta products
- IKK-alpha /IKK-beta
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抗原表位
- AA 120-200, pSer176, pSer177
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适用
- 小鼠, 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IKK-alpha /IKK-beta antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- IKKα/β is a protein encoded by the CHUK gene which is approximately 84,6 kDa. IKKα/β is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the TNFR1 pathway, the 4-1BB pathway, RET signalling and toll-like receptor signalling pathways. This protein falls under the serine/threonine protein kinase family. It has an essential role in the NF-kappa-B signalling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. It acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. These modifications allow for degradation by the proteasome. IKKα/β is widely expressed. Mutations in the CHUK gene result in Cocoon syndrome and incontinentia pigmenti. STJ90301 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous IKKα/β protein which only binds about S176/177 when S176/177 is phosphorylated.
- 特异性
- Phospho-IKKα/β (S176/177) Polyclonal Antibody detects endogenous levels of IKKα/β protein only when phosphorylated at S176/177.
- 产品特性
- Rabbit polyclonal to Phospho-IKKα/β (S176/177).
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from human IKKalpha/beta around the phosphorylation site of S176/177.
- 亚型
- IgG
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anti-IKK-alpha /IKK-beta (pSer180), (pSer181) antibody
适用: 小鼠, 人, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (pSer176), (pSer180) antibody适用: 小鼠, 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (AA 151-200), (pSer180) antibody适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (AA 151-250) antibody适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (Lys599) antibody适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (pSer176), (pSer180) antibody适用: 小鼠, 人 WB 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (pSer176), (pSer177) antibody适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (pSer180), (pSer181) antibody适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000 - 说明
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Widely expressed.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- 抗原
- IKK-alpha /IKK-beta
- 别名
- IKKalpha/beta (IKK-alpha /IKK-beta 产品)
- 分子量
- 80 kDa
- 基因ID
- 1147
- UniProt
- O15111
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