IKK-alpha /IKK-beta 抗体 (AA 151-250)
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- 抗原 See all IKK-alpha /IKK-beta products
- IKK-alpha /IKK-beta
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抗原表位
- AA 151-250
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IKK-alpha /IKK-beta antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
- 交叉反应
- 小鼠
- 预测反应
- Human,Rat,Dog,Cow,Pig,Horse,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human IKK Alpha/IKK beta
- 亚型
- IgG
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anti-IKK-alpha /IKK-beta (pSer180), (pSer181) antibody
适用: 小鼠, 人, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (pSer176), (pSer180) antibody适用: 小鼠, 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (AA 151-200), (pSer180) antibody适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (Lys599) antibody适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (pSer176), (pSer180) antibody适用: 小鼠, 人 WB 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (pSer176), (pSer177) antibody适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (pSer180), (pSer181) antibody适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IKK-alpha /IKK-beta (Lys6) antibody适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- IKK-alpha /IKK-beta
- 别名
- IKK alpha / beta (IKK-alpha /IKK-beta 产品)
- 背景
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Synonyms: IKK-Alpha, I kappa A kinase 2, I kappa A kinase Alpha, IkBKA, IKK 1, IKKA, IKK Alpha, IKK A, IKK Alpha, IKK1, IKKA, IKK-_, I kappa B kinase 2, I kappa B kinase beta, IkBKB, IKK 2, IKK_, IKK _, IKK B, IKK beta, IKK2, IKKB, Inhibitor of kappa light chain gene enhancer in B cells, Inhibitor of kappa light polypeptide gene enhancer in B cells, Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta, Inhibitor of nuclear factor kappa B kinase beta subunit, Inhibitor of nuclear factor kappa B kinase subunit beta, MGC131801, NFKBIKB, Nuclear factor NF kappa B inhibitor kinase beta, Nuclear factor of kappa light chain gene enhancer in B cells inhibitor.
Background: IKK Alpha/IKK beta is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
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