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IKK-alpha /IKK-beta 抗体 (AA 151-250)

适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1386118
发货至: 中国
  • 抗原 See all IKK-alpha /IKK-beta products
    IKK-alpha /IKK-beta
    抗原表位
    • 43
    • 26
    • 25
    • 14
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    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
    • 1
    • 1
    AA 151-250
    适用
    • 82
    • 61
    • 36
    • 3
    • 3
    • 3
    • 1
    • 1
    小鼠
    宿主
    • 90
    克隆类型
    • 82
    • 8
    多克隆
    标记
    • 22
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    This IKK-alpha /IKK-beta antibody is un-conjugated
    应用范围
    • 54
    • 40
    • 39
    • 25
    • 15
    • 11
    • 9
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    交叉反应
    小鼠
    预测反应
    Human,Rat,Dog,Cow,Pig,Horse,Chicken
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human IKK Alpha/IKK beta
    亚型
    IgG
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    IKK-alpha /IKK-beta
    别名
    IKK alpha / beta (IKK-alpha /IKK-beta 产品)
    背景

    Synonyms: IKK-Alpha, I kappa A kinase 2, I kappa A kinase Alpha, IkBKA, IKK 1, IKKA, IKK Alpha, IKK A, IKK Alpha, IKK1, IKKA, IKK-_, I kappa B kinase 2, I kappa B kinase beta, IkBKB, IKK 2, IKK_, IKK _, IKK B, IKK beta, IKK2, IKKB, Inhibitor of kappa light chain gene enhancer in B cells, Inhibitor of kappa light polypeptide gene enhancer in B cells, Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta, Inhibitor of nuclear factor kappa B kinase beta subunit, Inhibitor of nuclear factor kappa B kinase subunit beta, MGC131801, NFKBIKB, Nuclear factor NF kappa B inhibitor kinase beta, Nuclear factor of kappa light chain gene enhancer in B cells inhibitor.

    Background: IKK Alpha/IKK beta is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.

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