PAK4 抗体 (Internal Region)
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- 抗原 See all PAK4 抗体
- PAK4 (P21-Activated Kinase 4 (PAK4))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PAK4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- PAK4 Antibody detects endogenous levels of total PAK4.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PAK4, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PAK4 Primary Antibody
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anti-P21-Activated Kinase 4 (PAK4) (AA 299-542) antibody
PAK4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 1-426) antibodyPAK4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 187-216) antibodyPAK4 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 187-216) antibodyPAK4 适用: 人, 小鼠 WB, IHC, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) antibodyPAK4 适用: 人, 小鼠, 大鼠, Cow, 犬, 小鸡 WB, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (pSer474) antibodyPAK4 适用: 人, 小鼠, 大鼠, Cow, 犬, 小鸡 WB, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 23-72) antibodyPAK4 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 马, 斑马鱼, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 120-280) antibodyPAK4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 156-187) antibodyPAK4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 4 (PAK4) (AA 187-216) antibodyPAK4 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IHC 1:50-1:100, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PAK4 (P21-Activated Kinase 4 (PAK4))
- 别名
- PAK4 (PAK4 产品)
- 别名
- 5730488L07Rik antibody, AW555722 antibody, mKIAA1142 antibody, im:5916170 antibody, wu:fd12b01 antibody, zgc:92014 antibody, p21 (RAC1) activated kinase 4 antibody, p21 protein (Cdc42/Rac)-activated kinase 4 antibody, PAK4 antibody, Pak4 antibody, pak4 antibody
- 背景
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Description: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
Gene: PAK4
- 分子量
- 64kD
- 基因ID
- 10298
- UniProt
- O96013
- 途径
- RTK signaling
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