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PAK4 抗体 (AA 1-426)

Name: PAK4 抗体 (AA 1-426)
Brand: antibodies-online
SKU: ABIN7169132
Availability: OutOfStock

PAK4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

Western Blot Positive WB detected in: Rat lung tissue All lanes: PAK4 antibody at 3. (PAK4 抗体 (AA 1-426))

Immunofluorescence staining of Hela cells with ABIN7169132 at 1:266, counter-stained with DAPI. (PAK4 抗体 (AA 1-426))

IHC image of ABIN7169132 diluted at 1:800 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. (PAK4 抗体 (AA 1-426))

IHC

IHC image of ABIN7169132 diluted at 1:800 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. (PAK4 抗体 (AA 1-426))

IHC

4 images

产品编号 ABIN7169132

发货至: 中国

Datasheet as PDF

抗原 See all PAK4 抗体

PAK4 (P21-Activated Kinase 4 (PAK4))
抗原表位
14

9

8

6

6

6

6

4

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-426
适用
86

55

36

7

7

4

4

2

2

2

2

2

2

2

1
人
宿主
80

5

1
兔
Compatible Secondaries
克隆类型
80

6
多克隆
标记
42

7

6

5

4

4

2

2

2

2

2

2

1

1

1

1

1

1
This PAK4 antibody is un-conjugated
应用范围
70

37

20

18

8

8

7

7

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

交叉反应

人, 大鼠

纯化方法

>95%, Protein G purified

免疫原

Recombinant Human Serine/threonine-protein kinase PAK 4 protein (1-426AA)

亚型

IgG

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anti-P21-Activated Kinase 4 (PAK4) (AA 187-216) antibody
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anti-P21-Activated Kinase 4 (PAK4) (AA 187-216) antibody
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anti-P21-Activated Kinase 4 (PAK4) antibody
PAK4 适用: 人, 小鼠, 大鼠, Cow, 犬, 小鸡 WB, ELISA, IP 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 4 (PAK4) (pSer474) antibody
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anti-P21-Activated Kinase 4 (PAK4) (AA 23-72) antibody
PAK4 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 马, 斑马鱼, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 4 (PAK4) (AA 120-280) antibody
PAK4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 4 (PAK4) (AA 156-187) antibody
PAK4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 4 (PAK4) (AA 187-216) antibody
PAK4 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 4 (PAK4) (pSer474) antibody
PAK4 适用: 人, 小鼠, 大鼠, Cow WB, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:200-1:500,

限制

仅限研究用
状态

Liquid

缓冲液

Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

PAK4 (P21-Activated Kinase 4 (PAK4))

别名

PAK4 (PAK4 产品)

别名

5730488L07Rik antibody, AW555722 antibody, mKIAA1142 antibody, im:5916170 antibody, wu:fd12b01 antibody, zgc:92014 antibody, p21 (RAC1) activated kinase 4 antibody, p21 protein (Cdc42/Rac)-activated kinase 4 antibody, PAK4 antibody, Pak4 antibody, pak4 antibody

背景

Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
Aliases: KIAA1142 antibody, p21 activated kinase 4 antibody, p21 Cdc42/Rac1-actiated kinase 4 antibody, P21 protein (Cdc42/Rac) activated kinase 4 antibody, p21(CDKN1A) activated kinase 4 antibody, p21-activated kinase 4 antibody, PAK 4 antibody, PAK-4 antibody, Pak4 antibody, PAK4_HUMAN antibody, Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs antibody, Serine threonine kinase PAK 4 antibody, Serine/threonine protein kinase PAK 4 antibody, Serine/threonine protein kinase PAK4 antibody, Serine/threonine-protein kinase PAK 4 antibody

UniProt

O96013

途径

RTK signaling