alpha Adaptin 抗体 (Internal Region)
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- 抗原 See all alpha Adaptin (AP2A1) 抗体
- alpha Adaptin (AP2A1) (Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This alpha Adaptin antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- Alpha Adaptin Antibody detects endogenous levels of total alpha Adaptin.
- 预测反应
- Pig,Horse,Sheep,Rabbit
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human alpha Adaptin, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product AP2A1 Primary Antibody
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anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 706-727) antibody
Verified AP2A1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 1-260) antibodyAP2A1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) antibodyAP2A1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) antibodyAP2A1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 1-260) antibodyAP2A1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) antibodyAP2A1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 612-661) antibodyAP2A1 适用: 人, 小鼠, 大鼠, 马, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 3-14) antibodyAP2A1 适用: 人, 小鼠, 大鼠, 犬, 小鸡, Chimpanzee, Orang-Utan WB, ELISA, IP 宿主: 山羊 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 3-14) antibodyAP2A1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 706-735), (C-Term) antibodyAP2A1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB34053 unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- alpha Adaptin (AP2A1) (Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1))
- 别名
- AP2A1 (AP2A1 产品)
- 别名
- ADTAA antibody, AP2-ALPHA antibody, CLAPA1 antibody, adtaa antibody, clapa1 antibody, ap2-alpha antibody, AP2A1 antibody, Adtaa antibody, adaptor related protein complex 2 alpha 1 subunit antibody, adaptor-related protein complex 2, alpha 1 subunit antibody, AP-2 complex subunit alpha-1 antibody, AP2A1 antibody, ap2a1 antibody, Ap2a1 antibody, EDI_093420 antibody, EDI_259990 antibody
- 背景
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Description: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).
Gene: AP2A1
- 分子量
- 108 kDa
- 基因ID
- 160
- UniProt
- O95782
- 途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation
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