alpha Adaptin 抗体 (AA 1-260)
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北京 101111
Quick Overview for alpha Adaptin 抗体 (AA 1-260) (ABIN7144361)
抗原
See all alpha Adaptin (AP2A1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-260
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原理
- AP2A1 Antibody
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human AP-2 complex subunit alpha-1 protein (1-260AA)
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亚型
- IgG
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anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 706-727) antibody
Verified AP2A1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 1-260) antibodyAP2A1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) antibodyAP2A1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) antibodyAP2A1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 612-661) antibodyAP2A1 适用: 人, 小鼠, 大鼠, 马, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 706-735), (C-Term) antibodyAP2A1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB34053 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- alpha Adaptin (AP2A1) (Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1))
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别名
- AP2A1
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背景
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Background: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).
Aliases: 100 kDa coated vesicle protein A antibody, Adapter-related protein complex 2 alpha-1 subunit antibody, adapter-related protein complex 2 subunit alpha-1 antibody, Adaptin alpha A antibody, Adaptin alpha antibody, Adaptor protein complex AP 2 alpha 1 subunit antibody, adaptor protein complex AP 2 subunit alpha 1 antibody, Adaptor protein complex AP-2 subunit alpha-1 antibody, Adaptor protein complex AP2 alpha 1 subunit antibody, adaptor protein complex AP2 subunit alpha 1 antibody, Adaptor related protein complex 2 alpha 1 subunit antibody, Adaptor related protein complex AP 2 alpha 1 subunit antibody, Adaptor related protein complex AP2 alpha 1 subunit antibody, ADTAA antibody, Alpha A adaptin antibody, Alpha adaptin A antibody, Alpha-adaptin A antibody, alpha1 adaptin antibody, Alpha1-adaptin antibody, AP 2 alpha antibody, AP 2 complex subunit alpha 1 antibody, AP-2 complex subunit alpha-1 antibody, AP2 complex subunit alpha 1 antibody, AP2-ALPHA antibody, Ap2a1 antibody, AP2A1_HUMAN antibody, CLAPA 1 antibody, CLAPA1 antibody, Clathrin adaptor complex AP2. alpha subunit antibody, Clathrin assembly protein complex 2 alpha A large chain antibody, Clathrin assembly protein complex 2 alpha-A large chain antibody, Clathrin associated / assembly / adaptor protein large alpha 1 antibody, clathrin associated assembly adaptor protein large alpha 1 antibody, clathrin associated/assembly/adaptor protein, large, alpha 1 antibody, Plasma membrane adaptor HA 2/AP 2 adaptin alpha A subunit antibody, Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit antibody
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UniProt
- O95782
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途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation
抗原
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