p53 抗体 (C-Term)
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Quick Overview for p53 抗体 (C-Term) (ABIN6254175)
抗原
See all p53 (TP53) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-P53
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序列
- DRRTEEENLR KKGEPHHELP PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD
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特异性
- Detects endogenous levels of P53 by Western blot.
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产品特性
- Tumor protein p53
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纯化方法
- Epitope affinity purified
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免疫原
- Purified recombinant peptide derived from within residues 280 aa to the C-terminus of human P53 produced in E. coli.
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亚型
- IgG
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应用备注
- WB:1:500-1:2,000, IF:1:50-1:250
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限制
- 仅限研究用
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缓冲液
- PBS, 20 % glycerol and 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- The antibody solution should be gently mixed before use.
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储存条件
- 4 °C,-20 °C
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储存方法
- For continuous use, store at 2-8 C for one-two days. For extended storage, store in -20 C freezer. Working dilution samples should be discarded if not used within 12 hours.
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: "Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis." in: PLoS ONE, Vol. 14, Issue 10, pp. e0223790, (2020) (PubMed).
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- p53 (TP53) (Tumor Protein P53 (TP53))
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别名
- P53
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背景
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Goat polyclonal antibody to P53. This protein reacts to diverse cellular stresses to regulate target genes that induce apoptosis, senescence, cell cycle arrest, DNA repair, or changes in metabolism. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is assumed to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumour suppressor.
BCC7, LFS1 and TRP53 antibody.
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途径
- p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
抗原
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