Raptor 抗体 (AA 1005-1329)
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- 抗原 See all Raptor (RPTOR) 抗体
- Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))
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抗原表位
- AA 1005-1329
- 适用
- 人, 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Raptor antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
- 免疫原
- This RPTOR antibody is generated from a mouse immunized with recombinant protein.
- 克隆位点
- 1411CT316-2-151-34
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product RPTOR Primary Antibody
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anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) antibody
RPTOR 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 874-1009) antibodyRPTOR 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 6G9C4 unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 13-128) antibodyRPTOR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (C-Term) antibodyRPTOR 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (N-Term) antibodyRPTOR 适用: 人, 小鼠 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (C-Term) antibodyRPTOR 适用: 小鼠 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) antibodyRPTOR 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 14C4 unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) antibodyRPTOR 适用: 人 ELISA, IHC 宿主: 兔 Monoclonal 1B10 unconjugated Recombinant Antibody
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 1-379) antibodyRPTOR 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (pSer863) antibodyRPTOR 适用: 人 DB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:1000. IHC-P: 1:25
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))
- 别名
- RPTOR (RPTOR 产品)
- 别名
- KOG1 antibody, Mip1 antibody, 4932417H02Rik antibody, Rap antibody, Raptor antibody, mKIAA1303 antibody, RGD1311784 antibody, raptor antibody, regulatory associated protein of MTOR complex 1 antibody, regulatory associated protein of MTOR, complex 1 antibody, regulatory associated protein of MTOR, complex 1 L homeolog antibody, RPTOR antibody, Rptor antibody, rptor.L antibody, rptor antibody
- 背景
- Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals, functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.
- 分子量
- 149038
- UniProt
- Q8N122
- 途径
- PI3K-Akt Signaling, RTK signaling, AMPK Signaling, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Autophagy, BCR Signaling, Warburg Effect
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