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- 抗原 See all RAD23B 抗体
- RAD23B (RAD23 Homolog B (RAD23B))
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适用
- 人, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This RAD23B antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
- 免疫原
- Recombinant Protein
- Top Product
- Discover our top product RAD23B Primary Antibody
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anti-RAD23 Homolog B (RAD23B) (AA 1-409) antibody
RAD23B 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 311-409) antibodyRAD23B 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3H7 unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 1-409) antibodyRAD23B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 164-409) antibodyRAD23B 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (Center) antibodyRAD23B 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 163-176) antibodyRAD23B 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 24-120) antibodyRAD23B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), ICC, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (N-Term) antibodyRAD23B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 1-250) antibodyRAD23B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (N-Term) antibodyRAD23B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000. IHC: 1:100. ICC: 1:100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 储存条件
- 4 °C,-20 °C
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- 抗原
- RAD23B (RAD23 Homolog B (RAD23B))
- 别名
- hHR23b (RAD23B 产品)
- 别名
- HHR23B antibody, HR23B antibody, P58 antibody, 0610007D13Rik antibody, AV001138 antibody, mHR23B antibody, p58 antibody, MGC107846 antibody, zgc:65951 antibody, RAD23 homolog B, nucleotide excision repair protein antibody, UV excision repair protein RAD23 homolog B antibody, RAD23 homolog B, nucleotide excision repair protein S homeolog antibody, RAD23B antibody, Rad23b antibody, rd23b antibody, rad23b antibody, rad23b.S antibody
- 背景
- Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER, it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.
- UniProt
- P54727
- 途径
- DNA Damage Repair
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