ERK1/2 抗体 (pThr202, pTyr204)
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- 抗原 See all ERK1/2 (MAPK1/3) 抗体
- ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
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抗原表位
- AA 176-208, pThr202, pTyr204
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ERK1/2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- D, B, Rat, X, E
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This Phospho-Erk1/2(Thr202/Tyr204) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 176-208 amino acids from human Phospho-Erk1/2(Thr202/Tyr204).
- 克隆位点
- RB41825
- 亚型
- Ig Fraction
- Top Product
- Discover our top product MAPK1/3 Primary Antibody
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anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 301-358) antibody
MAPK1/3 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) antibodyMAPK1/3 适用: 人, 小鼠, 大鼠, Cow, Pig, 斑马鱼, 犬, 绵羊, 鱼, 马, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 300-380) antibodyMAPK1/3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) antibodyMAPK1/3 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr202), (pTyr204) antibodyMAPK1/3 适用: 人, 小鼠, 大鼠, Cow WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr183), (pTyr185) antibodyMAPK1/3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr185), (pThr202) antibodyMAPK1/3 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (C-Term) antibodyMAPK1/3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) antibodyMAPK1/3 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr202), (pTyr204) antibodyMAPK1/3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000. WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
- 别名
- Erk1/2 (MAPK1/3 产品)
- 别名
- erk1/2 antibody, mitogen-activated protein kinase antibody, erk1/2 antibody
- 背景
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
- 分子量
- 43136
- UniProt
- P27361
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