-
- 抗原 See all EGLN1 抗体
- EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This EGLN1 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human EGLN1
- 亚型
- IgG
-
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 1-426) antibody
KO Validated EGLN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) antibodyEGLN1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 300-400) antibodyEGLN1 适用: 小鼠 WB, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) antibodyEGLN1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 42-140) antibodyEGLN1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 301-426) antibodyEGLN1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 272-355) antibodyEGLN1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (Internal Region) antibodyEGLN1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 350-426) antibodyEGLN1 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) antibodyEGLN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid freeze / thaw cycles
- 储存条件
- -20 °C/-80 °C
-
- 抗原
- EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
- 别名
- EGLN1 (EGLN1 产品)
- 别名
- EGLN1 antibody, egln2 antibody, phd2 antibody, zgc:92314 antibody, AI503754 antibody, C1orf12 antibody, HIF-PH2 antibody, HPH-2 antibody, Hif-p4h-2 antibody, ORF13 antibody, Phd2 antibody, SM-20 antibody, PHD-2 antibody, PHD2 antibody, ECYT3 antibody, HIFPH2 antibody, HPH2 antibody, SM20 antibody, ZMYND6 antibody, egl nine homolog 1 (C. elegans) antibody, egl-9 family hypoxia inducible factor 1 antibody, egl-9 family hypoxia-inducible factor 1 S homeolog antibody, egl-9 family hypoxia-inducible factor 1b antibody, egl-9 family hypoxia-inducible factor 1 antibody, EGLN1 antibody, egln1.S antibody, egln1b antibody, Egln1 antibody
- 背景
-
PHD1 (Egln2), PHD-2 (Egln1), and PHD3 (Egln3) are members of the Egln family of proline hydroxylases. They function as oxygen sensors that catalyze the hydroxylation of HIF on prolines 564 and 402, initiating the first step of HIF degradation through the VHL/ubiquitin pathway. PHD1 is highly expressed in a wide array of tissues whereas PHD2 and PHD3 are expressed mainly in heart and skeletal muscle. The mRNA levels of PHD are upregulated by HIF through the hypoxia-response element under low oxygen conditions. These three enzymes also exhibit different peptide specificity target proteins, PHD1 and PHD2 can hydroxylate both proline 402 and proline 564, but PHD3 can only hydroxylate proline 564. In addition to HIF, PHD enzymes have also has been shown to catalyze the hydroxylation of RNA polymerase subunits and myogenin.
Synonyms: EGLN1, C1orf12, DKFZp761F179, ECYT3, HIFPH2, HPH2, PHD2, SM-20, SM20, ZMYND6 - 基因ID
- 54583
- UniProt
- Q9GZT9
- 途径
- cAMP Metabolic Process, Warburg Effect
-
You are here:
