EGLN1 产品
(Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
Categories
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009].
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Featured EGLN1 Categories
EGLN1 抗体
High quality antibodies with extensive validation data.
EGLN1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
EGLN1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended EGLN1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (6)
Cat. No.
ABIN3021560
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
Cat. No.
ABIN7266909
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (5)
Cat. No.
ABIN7255273
Quantity
200 μL
Datasheet
Datasheet
Recommended EGLN1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955511
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955510
Quantity
96 tests
Datasheet
Datasheet
Recommended EGLN1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352445
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352443
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3092287
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our EGLN1 Products
: "Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis. ..." in: Nature communications, Vol. 9, Issue 1, pp. 5426, (2019) (PubMed).: "Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses. ..." in: Nature communications, Vol. 10, Issue 1, pp. 903, (2019) (PubMed).
: "Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages." in: Cell reports, Vol. 27, Issue 13, pp. 3873-3886.e7, (2019) (PubMed).
: "A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension." in: Nature communications, Vol. 10, Issue 1, pp. 2130, (2019) (PubMed).
: "Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. ..." in: The Journal of clinical investigation, Vol. 130, pp. 3640-3656, (2019) (PubMed).
: "The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia." in: Cell metabolism, Vol. 27, Issue 4, pp. 898-913.e7, (2018) (PubMed).
: "Intermittent hypoxia induces beneficial cardiovascular remodeling in left ventricular function of type 1 diabetic rat." in: Anatolian journal of cardiology, Vol. 19, Issue 4, pp. 259-266, (2018) (PubMed).
: "Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen." in: Nature communications, Vol. 9, Issue 1, pp. 4545, (2018) (PubMed).
: "The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels." in: eLife, Vol. 6, (2017) (PubMed).
: "Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice." in: Journal of cellular and molecular medicine, (2017) (PubMed).
Synonyms and alternative names related to EGLN1
egl nine homolog 1 (C. elegans) (EGLN1), egl-9 family hypoxia inducible factor 1 (EGLN1), egl-9 family hypoxia-inducible factor 1 S homeolog (egln1.S), egl-9 family hypoxia-inducible factor 1b (egln1b), egl-9 family hypoxia-inducible factor 1 (Egln1), AI503754, C1orf12, ECYT3, EGLN1, egln2, Hif-p4h-2, HIF-PH2, HIFPH2, HPH-2, HPH2, ORF13, PHD-2, phd2, Phd2, PHD2, SM-20, SM20, zgc:92314, ZMYND6Protein level used designations for EGLN1
- egl nine homolog 1 (C. elegans)
- egl nine homolog 1
- egl nine homolog 1-like
- egl nine homolog 2
- Hif-p4h-2
- HIF-prolyl hydroxylase 2
- hypoxia-inducible factor prolyl hydroxylase 2
- prolyl hydroxylase domain-containing protein 2
- HIF prolyl hydroxylase 2
- egl nine-like protein 1
- zinc finger MYND domain-containing protein 6
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