EGLN1 蛋白
(Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009].
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11 results
EGLN1
宿主: 人
宿主: Baculovirus infected Insect Cells
Recombinant
AcA, Func, ScA
Aliases for EGLN1 蛋白
egl nine homolog 1 (C. elegans) (EGLN1) 蛋白egl-9 family hypoxia inducible factor 1 (EGLN1) 蛋白
egl-9 family hypoxia-inducible factor 1 S homeolog (egln1.S) 蛋白
egl-9 family hypoxia-inducible factor 1b (egln1b) 蛋白
egl-9 family hypoxia-inducible factor 1 (Egln1) 蛋白
AI503754 蛋白
C1orf12 蛋白
ECYT3 蛋白
EGLN1 蛋白
egln2 蛋白
Hif-p4h-2 蛋白
HIF-PH2 蛋白
HIFPH2 蛋白
HPH-2 蛋白
HPH2 蛋白
ORF13 蛋白
PHD-2 蛋白
phd2 蛋白
Phd2 蛋白
PHD2 蛋白
SM-20 蛋白
SM20 蛋白
zgc:92314 蛋白
ZMYND6 蛋白
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