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- 抗原 See all EGLN1 抗体
- EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
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抗原表位
- AA 301-426
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This EGLN1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人, 大鼠
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Egl nine homolog 1 protein (301-426AA)
- 亚型
- IgG
- Top Product
- Discover our top product EGLN1 Primary Antibody
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anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) antibody
EGLN1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 1-426) antibodyKO Validated EGLN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) antibodyEGLN1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 300-400) antibodyEGLN1 适用: 小鼠 WB, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) antibodyEGLN1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 42-140) antibodyEGLN1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 272-355) antibodyEGLN1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (Internal Region) antibodyEGLN1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 350-426) antibodyEGLN1 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) antibodyEGLN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
- 别名
- EGLN1 (EGLN1 产品)
- 别名
- EGLN1 antibody, egln2 antibody, phd2 antibody, zgc:92314 antibody, AI503754 antibody, C1orf12 antibody, HIF-PH2 antibody, HPH-2 antibody, Hif-p4h-2 antibody, ORF13 antibody, Phd2 antibody, SM-20 antibody, PHD-2 antibody, PHD2 antibody, ECYT3 antibody, HIFPH2 antibody, HPH2 antibody, SM20 antibody, ZMYND6 antibody, egl nine homolog 1 (C. elegans) antibody, egl-9 family hypoxia inducible factor 1 antibody, egl-9 family hypoxia-inducible factor 1 S homeolog antibody, egl-9 family hypoxia-inducible factor 1b antibody, egl-9 family hypoxia-inducible factor 1 antibody, EGLN1 antibody, egln1.S antibody, egln1b antibody, Egln1 antibody
- 背景
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Background: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferencially recognized via a LXXLAP motif.
Aliases: C1ORF12 antibody, Chromosome 1 Open Reading Frame 12 antibody, DKFZp761F179 antibody, ECYT 3 antibody, ECYT3 antibody, Egl 9 family hypoxia inducible factor 1 antibody, EGL 9 homolog of C. elegans 1 antibody, EGL nine (C.elegans) homolog 1 antibody, Egl nine homolog 1 (C. elegans) antibody, Egl nine homolog 1 antibody, Egl nine like protein 1 antibody, EGLN 1 antibody, Egln1 antibody, EGLN1_HUMAN antibody, HIF PH2 antibody, HIF Prolyl Hydroxylase 2 antibody, HIF-PH2 antibody, HIF-prolyl hydroxylase 2 antibody, HIFP4H 2 antibody, HIFPH2 antibody, HPH 2 antibody, HPH-2 antibody, HPH2 antibody, Hypoxia inducible factor prolyl hydroxylase 2 antibody, Hypoxia-inducible factor prolyl hydroxylase 2 antibody, ORF13 antibody, P4H2 antibody, PHD 2 antibody, PhD2 antibody, PNAS 118 antibody, PNAS 137 antibody, Prolyl Hydroxylase Domain Containing Protein 2 antibody, Prolyl hydroxylase domain-containing protein 2 antibody, Rat Homolog of SM20 antibody, SM 20 antibody, SM-20 antibody, SM20 antibody, Zinc finger MYND domain containing protein 6 antibody, ZMYND6 antibody
- UniProt
- Q9GZT9
- 途径
- cAMP Metabolic Process, Warburg Effect
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