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Insulin Receptor 抗体 (N-Term)

Name: Insulin Receptor 抗体 (N-Term)
Brand: antibodies-online
SKU: ABIN1513096
Availability: OutOfStock

INSR 适用: 人, 大鼠 WB, IP, ICC 宿主: 兔 Polyclonal unconjugated

Western Blotting (WB) image for anti-Insulin Receptor (INSR) (N-Term) antibody (ABIN1513096) (Insulin Receptor 抗体 (N-Term))

1 image

产品编号 ABIN1513096

发货至: 中国

Datasheet as PDF

抗原 See all Insulin Receptor (INSR) 抗体

Insulin Receptor (INSR)
抗原表位
16

14

13

12

9

8

8

7

6

6

5

5

5

4

4

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
168

96

80

16

14

9

8

7

6

5

4

3

2

2

1

1

1

1

1

1

1
人, 大鼠
宿主
165

23

3

1
兔
Compatible Secondaries
克隆类型
157

35
多克隆
标记
117

16

16

7

6

5

3

3

3

3

3

3

1

1

1

1

1

1

1
This Insulin Receptor antibody is un-conjugated
应用范围
140

82

52

27

16

15

15

15

13

13

8

5

4

4

4

2

1

1

1

1
Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

纯化方法

Affinity purification

免疫原

N term -peptide of human INSR

亚型

IgG

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INSR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 1027-1364) antibody
INSR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

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INSR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor (INSR) (C-Term) antibody
INSR 适用: 人, 小鼠, 大鼠, 猴, 犬, 马, Cow, 豚鼠, 兔, Pig, 小鸡, 绵羊, Hamster, Avian, Cat, 驴, 山羊 WB 宿主: 山羊 Polyclonal unconjugated

anti-Insulin Receptor (INSR) (C-Term) antibody
KO Validated INSR 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 51-150) antibody
INSR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 1325-1358) antibody
INSR 适用: 小鼠 WB 宿主: 兔 Polyclonal RB50340 unconjugated

anti-Insulin Receptor (INSR) (AA 1023-1298) antibody
INSR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 27-57), (N-Term) antibody
INSR 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1421 unconjugated

应用备注

Recommended dilutions: WB: 1:500-1:2000, ICC: 1:50-1:200, IP: 1:20-1:50

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze / thaw cycles

储存条件

-20 °C/-80 °C
抗原

Insulin Receptor (INSR)

别名

INSR (INSR 产品)

别名

CD220 antibody, HHF5 antibody, 4932439J01Rik antibody, D630014A15Rik antibody, IR antibody, IR-A antibody, IR-B antibody, 18402 antibody, CG18402 antibody, DIHR antibody, DILR antibody, DIR antibody, DIRH antibody, DIRbeta antibody, DInR antibody, DInr antibody, Dir-a antibody, Dir-b antibody, Dmel\\CG18402 antibody, INR antibody, INS antibody, Inr antibody, Inr-alpha antibody, Inr-beta antibody, InsR antibody, dINR antibody, dIR antibody, dIRH antibody, dInR antibody, dInr antibody, dInsR antibody, dinr antibody, dir antibody, er10 antibody, inr antibody, insulin/insulin-like growth factor receptor antibody, l(3)05545 antibody, l(3)93Dj antibody, l(3)er10 antibody, lnR antibody, ir-A antibody, CTK-1 antibody, ir antibody, INSR antibody, NV14476 antibody, cd220 antibody, hhf5 antibody, insulin receptor antibody, Insulin-like receptor antibody, insulin receptor L homeolog antibody, INSR antibody, Insr antibody, InR antibody, LOC100122567 antibody, LOC100451802 antibody, insr.L antibody

背景

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation. 1. Adams, T.E. et al. Cell. Mol. Life Sci. 57, 1050-1093. 2. Baserga, R. et al. Oncogene 19, 5574-5581. 3. Scheidegger, K.J. et al. J. Biol. Chem. 275, 38921-38928. 4. Hernandez-Sanchez, C. et al. J. Biol. Chem. 270, 29176-29181. 5. Lopaczynski, W. et al. Biochem. Biophys. Res. Commun. 279, 955-960. 6. Baserga, R. et al. Exp. Cell Res. 253, 1-6. 7. White, M.F. et al. J. Biol. Chem. 260, 9470-9478. 8. White, M.F. et al. J. Biol. Chem. 263, 2969-2980.
Synonyms: INSR, CD220, HHF5 , Insulin Receptor beta

基因ID

3643

UniProt

P06213

途径

NF-kappaB Signaling, RTK signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity