HLA-DRB1 抗体 (CF®594)
-
- 抗原 See all HLA-DRB1 抗体
- HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
-
适用
- 人, 猴, 犬, Squirrel, Baboon, Chimpanzee
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This HLA-DRB1 antibody is conjugated to CF®594
-
应用范围
- Flow Cytometry (FACS), Immunofluorescence (IF)
- 原理
- Mouse Monoclonal anti-HLA-DRB (L243), CF594 Conjugate
- 产品特性
- This MAb reacts with the HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. It binds a conformational epitope on HLA-DR, which depends on the correct folding of the α/β heterodimer. This MAb has been reported to block mixed lymphocyte reactions. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kD alpha (heavy) chain and a 28kD beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- 免疫原
- Activated human peripheral blood mononuclear cells
- 克隆位点
- L243
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product HLA-DRB1 Primary Antibody
-
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-266) antibody
HLA-DRB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人, 猴 WB, FACS, IF, IHC, ISt, StM 宿主: 小鼠 Monoclonal LN-3 unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 27-264) antibodyHLA-DRB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 WB, IF, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 1-266) antibodyHLA-DRB1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 IHC 宿主: 兔 Monoclonal MSVA-478R unconjugated Recombinant Antibody
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-58) antibodyHLA-DRB1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21019 unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-266) antibodyHLA-DRB1 适用: 人 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 31-266) antibody (Biotin)HLA-DRB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal Biotin
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Optimal dilution for a specific application should be determined by user
- 说明
-
Ramos, Daudi or HuT78 cells. Tonsil or lymph node
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 100 μg/mL
- 缓冲液
- PBS/0.1 % BSA/0.05 % azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Protect from light
-
- 抗原
- HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
- 别名
- HLA-DRB (HLA-DRB1 产品)
- 别名
- MGC108235 antibody, DRB1 antibody, DRw10 antibody, HLA-DR1B antibody, HLA-DRB antibody, SS1 antibody, major histocompatibility complex, class II, DR beta 1 antibody, hla-drb1 antibody, HLA-DRB1 antibody
- 分子量
- 28 kDa (beta chain)
- 基因ID
- 3123, 534322
- UniProt
- P01911
- 途径
- TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Cancer Immune Checkpoints
-
