HLA-DRB1 抗体
(1 reference)-
- 抗原 See all HLA-DRB1 抗体
- HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HLA-DRB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- 交叉反应
- 人
- 产品特性
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Rabbit Polyclonal antibody to HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)
HLA-DRB1 antibody [N1C3] - 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein encompassing a sequence within the center region of human HLA-DRB1. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product HLA-DRB1 Primary Antibody
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anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-266) antibody
HLA-DRB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人, 猴 WB, FACS, IF, IHC, ISt, StM 宿主: 小鼠 Monoclonal LN-3 unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 27-264) antibodyHLA-DRB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 1-266) antibodyHLA-DRB1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 IHC 宿主: 兔 Monoclonal MSVA-478R unconjugated Recombinant Antibody
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-58) antibodyHLA-DRB1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21019 unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-266) antibodyHLA-DRB1 适用: 人 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 31-266) antibody (Biotin)HLA-DRB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal Biotin
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 FACS, IHC (p) 宿主: 小鼠 Monoclonal WR18 unconjugated
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- 应用备注
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.68 mg/mL
- 缓冲液
- 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration." in: Aging, Vol. 9, Issue 3, pp. 823-851, (2017) (PubMed).
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: "Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration." in: Aging, Vol. 9, Issue 3, pp. 823-851, (2017) (PubMed).
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- 抗原
- HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
- 别名
- major histocompatibility complex, class II, DR beta 1 (HLA-DRB1 产品)
- 别名
- MGC108235 antibody, DRB1 antibody, DRw10 antibody, HLA-DR1B antibody, HLA-DRB antibody, SS1 antibody, major histocompatibility complex, class II, DR beta 1 antibody, hla-drb1 antibody, HLA-DRB1 antibody
- 背景
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HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain, and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
- 基因ID
- 3123
- UniProt
- P01911, P01912, Q29974
- 途径
- TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Cancer Immune Checkpoints
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