HLA-DRB1 抗体
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- 抗原 See all HLA-DRB1 抗体
- HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
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适用
- 人, 猴
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This HLA-DRB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunostaining (ISt), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 原理
- Mouse Monoclonal anti-HLA-DRB (HLA-DRB/1067), Purified, BSA-free
- 产品特性
- This MAb reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. Its epitope is different from that of MAb L243. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- 纯化方法
- Purified
- 免疫原
- Activated human peripheral blood mononuclear cells
- 克隆位点
- HLA-DRB-1067
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product HLA-DRB1 Primary Antibody
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anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-266) antibody
HLA-DRB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人, 猴 WB, FACS, IF, IHC, ISt, StM 宿主: 小鼠 Monoclonal LN-3 unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 27-264) antibodyHLA-DRB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 WB, IF, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 1-266) antibodyHLA-DRB1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 IHC 宿主: 兔 Monoclonal MSVA-478R unconjugated Recombinant Antibody
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-58) antibodyHLA-DRB1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21019 unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-266) antibodyHLA-DRB1 适用: 人 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 31-266) antibody (Biotin)HLA-DRB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal Biotin
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistology formalin-fixed 0.25-0.5 μg/mL
- Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
- Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Western blotting 0.5-1 μg/mL
- Optimal dilution for a specific application should be determined by user
- 说明
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Ramos, Daudi or HuT78 cells. Tonsil or lymph node
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS (no BSA, no azide)
- 储存液
- Azide free
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- 抗原
- HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
- 别名
- HLA-DRB (HLA-DRB1 产品)
- 别名
- MGC108235 antibody, DRB1 antibody, DRw10 antibody, HLA-DR1B antibody, HLA-DRB antibody, SS1 antibody, major histocompatibility complex, class II, DR beta 1 antibody, hla-drb1 antibody, HLA-DRB1 antibody
- 分子量
- 28 kDa (beta chain)
- 基因ID
- 3123, 534322
- UniProt
- P01911
- 途径
- TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Cancer Immune Checkpoints
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