BRCA1 抗体 (AA 445-620)
-
- 抗原 See all BRCA1 抗体
- BRCA1 (Breast Cancer 1 (BRCA1))
-
抗原表位
- AA 445-620
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This BRCA1 antibody is un-conjugated
-
应用范围
- ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Coating (Coat)
- 原理
- Mouse Monoclonal anti-BRCA1 (BRCA1/1472), Purified, BSA-free
- 产品特性
- BRCA1 is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and also acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). It associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. It plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in BRCA1 are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- 纯化方法
- Purified
- 免疫原
- Recombinant human BRCA1 protein fragment (aa445-620) (exact sequence is proprietary)
- 克隆位点
- BRCA1-1472
- 亚型
- IgG1
- Top Product
- Discover our top product BRCA1 Primary Antibody
-
anti-Breast Cancer 1 (BRCA1) (AA 120-220) antibody
BRCA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 19-83) antibodyBRCA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (pSer1423) antibodyBRCA1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 229-335) antibodyBRCA1 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 6C6D2 unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 400-699) antibodyBRCA1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 1661-1863) antibodyBRCA1 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) antibodyBRCA1 适用: 人, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (Ser184) antibodyBRCA1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (Ser184), (Ser186) antibodyBRCA1 适用: 人, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 445-620) antibodyBRCA1 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal BRCA1-1398 unconjugated
-
- 应用备注
-
Immunofluorescence 1-2 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- ELISA For coating, order Ab without BSA
- Optimal dilution for a specific application should be determined by user
- 说明
-
A431 or HeLa Cells. Breast, Ovarian or Renal Cell Carcinoma
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS (no BSA, no azide)
- 储存液
- Azide free
-
- 抗原
- BRCA1 (Breast Cancer 1 (BRCA1))
- 别名
- BRCA1 (BRCA1 产品)
- 别名
- BRCAI antibody, BRCC1 antibody, BROVCA1 antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, PSCP antibody, RNF53 antibody, iris antibody, pscp antibody, brcai antibody, brcc1 antibody, rnf53 antibody, brca1 antibody, BRCA1 antibody, LOC100224649 antibody, BRCA1, DNA repair associated antibody, breast cancer 1 antibody, breast cancer 1, early onset antibody, breast cancer 1 L homeolog antibody, BRCA1 antibody, brca1 antibody, LOC755086 antibody, Brca1 antibody, brca1.L antibody
- 分子量
- 220 kDa
- 基因ID
- 672, 194143
- UniProt
- P38398
- 途径
- Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
-
