我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

BRCA1 抗体 (AA 1661-1863)

Name: BRCA1 抗体 (AA 1661-1863)
SKU: ABIN3044313
Availability: OutOfStock

BRCA1 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Anti-BRCA1 Picoband antibody, All lanes: Anti-BRCA1 at 0. (BRCA1 抗体 (AA 1661-1863))

Anti-BRCA1 Picoband antibody, IHC(P): Human Mammary Cancer Tissue (BRCA1 抗体 (AA 1661-1863))

IHC

Anti-BRCA1 Picoband antibody, IHC(P): Rat Testis Tissue (BRCA1 抗体 (AA 1661-1863))

IHC

Anti-BRCA1 Picoband antibody, IHC(P): Mouse Testis Tissue (BRCA1 抗体 (AA 1661-1863))

IHC

4 images

(2 references)

产品编号 ABIN3044313

发货至: 中国

Datasheet as PDF

抗原 See all BRCA1 抗体

BRCA1 (Breast Cancer 1 (BRCA1))
抗原表位
22

18

15

15

14

11

10

9

8

7

6

6

5

5

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1661-1863
适用
192

35

24

3

2

1

1

1
人, 大鼠, 小鼠
宿主
161

37

2
兔
Compatible Secondaries
克隆类型
165

35
多克隆
标记
93

18

9

7

7

7

7

7

7

7

3

3

3

3

3

2

2

2

2

2

2

2

2
This BRCA1 antibody is un-conjugated
应用范围
126

67

42

42

41

37

28

24

22

12

12

10

9

9

3

2

2

2

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

原理

Rabbit IgG polyclonal antibody for Breast cancer type 1 susceptibility protein(BRCA1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

品牌

Picoband™

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for Breast cancer type 1 susceptibility protein(BRCA1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: breast cancer 1, early onset
Protein Name: Breast cancer type 1 susceptibility protein

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human BRCA1 recombinant protein (Position: E1661-Y1863). Human BRCA1 shares 65% and 66% amino acid (aa) sequence identity with mouse and rat BRCA1, respectively.

亚型

IgG

Top Product

Discover our top product BRCA1 Primary Antibody
anti-Breast Cancer 1 (BRCA1) (AA 120-220) antibody
BRCA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 19-83) antibody
BRCA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (pSer1423) antibody
BRCA1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 229-335) antibody
BRCA1 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 6C6D2 unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 400-699) antibody
BRCA1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) antibody
BRCA1 适用: 人, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (Ser184) antibody
BRCA1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (Ser184), (Ser186) antibody
BRCA1 适用: 人, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 445-620) antibody
BRCA1 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal BRCA1-1398 unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 1314-1864) antibody
BRCA1 适用: 人 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal KEN unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Liu, Lai, Li, Sun, Cheng, Ge, Wang, Li, Zhang, De Felici, Dyce, Shen: "Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro." in: Cell death & disease, Vol. 8, Issue 8, pp. e2966, (2017) (PubMed).

Zhang, Zhang, Cong, Zhang: "The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients." in: Diagnostic pathology, Vol. 7, pp. 181, (2013) (PubMed).
抗原

BRCA1 (Breast Cancer 1 (BRCA1))

别名

BRCA1 (BRCA1 产品)

别名

BRCAI antibody, BRCC1 antibody, BROVCA1 antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, PSCP antibody, RNF53 antibody, iris antibody, pscp antibody, brcai antibody, brcc1 antibody, rnf53 antibody, brca1 antibody, BRCA1 antibody, LOC100224649 antibody, BRCA1, DNA repair associated antibody, breast cancer 1 antibody, breast cancer 1, early onset antibody, breast cancer 1 L homeolog antibody, BRCA1 antibody, brca1 antibody, LOC755086 antibody, Brca1 antibody, brca1.L antibody

背景

BRCA1, also known as BRCC1, is a gene which mapping to 17q21.3. This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. In addition to it, BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth and that this function is compromised in breast cancer either by direct mutation or by alterations in gene expression.

Synonyms: BRAC 1 antibody|BRCA 1 antibody|BRCA1 antibody|BRCA1/BRCA2 containing complex subunit 1 antibody|BRCA1/BRCA2-containing complex, subunit 1 antibody|BRCA1_HUMAN antibody|BRCAI antibody|BRCC 1 antibody|BRCC1 antibody|Breast and ovarian cancer susceptibility protein 1 antibody|Breast Cancer 1 antibody|Breast Cancer 1 Early Onset antibody|Breast cancer type 1 susceptibility protein antibody|Breast Ovarian Cancer Susceptibility antibody|Breast Ovarian Cancer Susceptibility antibody|BROVCA1 antibody|IRIS antibody|Papillary Serous Carcinoma Of The Peritoneum antibody|PNCA4 antibody|PPP1R53 antibody|Protein phosphatase 1 regulatory subunit 53 antibody|PSCP antibody|RING finger protein 53 antibody|RING finger protein 53 antibody|RNF53 antibody

基因ID

672

UniProt

P38398

途径

Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus