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Angiotensin II Type-1 Receptor 抗体

AGTR1 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN615708
发货至: 中国
  • 抗原 See all Angiotensin II Type-1 Receptor (AGTR1) 抗体
    Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))
    适用
    • 50
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    • 5
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    人, 大鼠, 小鼠
    宿主
    • 48
    • 3
    • 2
    • 1
    • 1
    克隆类型
    • 52
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    多克隆
    标记
    • 33
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    This Angiotensin II Type-1 Receptor antibody is un-conjugated
    应用范围
    • 32
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody reacts to the internal region of Angiotensin II Type 1 Receptor (AGTR1).
    纯化方法
    Immunoaffinity Chromatography
    免疫原
    Synthetic peptide - KLH conjugated, Synthetic peptide Genename: AGTR1
    Top Product
    Discover our top product AGTR1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    1,0 mg/mL
    缓冲液
    PBS containing 0.02 % sodium azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))
    别名
    Type-1 Angiotensin II Receptor (AT1) (AGTR1 产品)
    别名
    AG2S antibody, AGTR1A antibody, AGTR1B antibody, AT1 antibody, AT1AR antibody, AT1B antibody, AT1BR antibody, AT1R antibody, AT2R1 antibody, AT2R1A antibody, AT2R1B antibody, HAT1R antibody, 1810074K20Rik antibody, AI551199 antibody, AT1a antibody, Agtr-1a antibody, Agtr1 antibody, Angtr-1a antibody, AT1A antibody, XAT-1 antibody, agtr1-A antibody, agtr1.2 antibody, AT1-R antibody, at1 antibody, AGTR1 antibody, Agtr-1b antibody, Angtr-1b antibody, agtr1 antibody, agtr1-a antibody, agtr1-b antibody, xAT antibody, angiotensin II receptor type 1 antibody, angiotensin II receptor, type 1a antibody, angiotensin II receptor type 1 S homeolog antibody, uncharacterized AGTR1 antibody, angiotensin II receptor, type 1b antibody, angiotensin II receptor type 1 L homeolog antibody, AGTR1 antibody, Agtr1a antibody, agtr1.S antibody, Agtr1 antibody, Agtr1b antibody, agtr1.L antibody
    背景
    Type 1 Angiotensin Receptors (AT1A and AT1B) mediate the major cardiovascular effects of angiotensin II, controlling blood pressure and volume by regulating cell growth, vascular contraction, inflammatory responses, and salt and water retention. Stimulation of AT1 receptors by Ang II activates phospholipase C beta, resulting in increased intracellular calcium and inositol 1, 4, 5-triphosphate concentrations, and activatesthe mitogen-activated protein kinases, such as extracellular regulated kinases, by way of Src and Ras as well as the JAK/STAT pathways. AT1 knock-out mice have lower blood pressure than wild type mice and lose normal pressor response to exogenous Ang II. AT1B differs from AT1A in its mRNA tissue distribution and in the 5' untranslated region. AT1 blockers have become widely used in the treatment of hypertension and may offer benefits other than blood pressure reduction.Synonyms: AGTR1, AGTR1A, AGTR1B, AT1AR, AT1BR, AT2R1, AT2R1B
    基因ID
    185
    NCBI登录号
    NP_000676
    UniProt
    P30556
    途径
    JAK/STAT Signaling, ACE Inhibitor Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
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