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CHEK1 抗体 (Ser286)

Name: CHEK1 抗体 (Ser286)
SKU: ABIN5961567
Availability: OutOfStock

This anti-CHEK1 antibody is a 兔多克隆 antibody detecting CHEK1 in WB, ELISA, IF 和 IHC (p). Suitable for 人.

Western Blotting (WB) image for anti-Checkpoint Kinase 1 (CHEK1) (Ser286) antibody (ABIN5961567) (CHEK1 抗体 (Ser286))

1 image

产品编号 ABIN5961567

发货至: 中国

Quick Overview for CHEK1 抗体 (Ser286) (ABIN5961567)

抗原

See all CHEK1 抗体

CHEK1 (Checkpoint Kinase 1 (CHEK1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This CHEK1 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Discover our top product CHEK1 Primary Antibody

抗原表位
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Ser286

特异性

C85740,Cell cycle checkpoint kinase,Checkpoint,S. pombe,homolog of,1,Checkpoint kinase 1,Checkpoint kinase 1 homolog (S. pombe),CHEK 1,Chek1,Chk 1,Chk1,CHK1 checkpoint homolog (S. pombe),CHK1,EC 2.7.11.1,rad27,Serine/threonine protein kinase Chk1,Serine/threonine-protein kinase CHK1,STT3,subunit of the oligosaccharyltransferase complex,homolog A (S. cerevisiae)

纯化方法

Affinity purification

免疫原

Synthesized peptide derived from human Chk1 around the non-phosphorylation site of Ser286.

亚型

IgG
anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer301) antibody
CHEK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer296) antibody
CHEK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer286) antibody
CHEK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer345) antibody
CHEK1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (Middle Region) antibody
CHEK1 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 适用: 小鼠, 小鸡 ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) antibody
CHEK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Monoclonal 2F2 unconjugated Recombinant Antibody

anti-Checkpoint Kinase 1 (CHEK1) antibody
CHEK1 适用: 人, 小鼠 WB, ELISA 宿主: 小鼠 Monoclonal 2G1D5 unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 适用: 人 WB, IHC (p), DB 宿主: 兔 Polyclonal RB7845-RB18425 unconjugated

应用备注

WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000

限制

仅限研究用
浓度

1 mg/mL

缓冲液

PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
抗原

CHEK1 (Checkpoint Kinase 1 (CHEK1))

别名

Chk1

背景

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both function as essential components in the G2 DNA damage checkpoint by phosphorylating Cdc25C in response to DNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown that Chk1 can phosphorylate Wee 1 in vitro, providing evidence that the hyperphosphorylated form of Wee 1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation by Chk1.

分子量

54kDa

基因ID

1111

UniProt

O14757

途径

p53 Pathway, Apoptosis, Cell Division Cycle, DNA Damage Repair