Optimal working dilution should be determined by the investigator.
限制
仅限研究用
缓冲液
PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freeze / thaw cycles.
储存条件
-20 °C
有效期
12 months
抗原
CHEK1
(Checkpoint Kinase 1 (CHEK1))
别名
Chk1
背景
Synonyms: Background:The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.