TSEN2 抗体
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- 抗原 See all TSEN2 抗体
- TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TSEN2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 免疫原
- tRNA splicing endonuclease 2 homolog (S. cerevisiae)
- 亚型
- IgG
- Top Product
- Discover our top product TSEN2 Primary Antibody
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- 应用备注
- WB:1:500-1:5000
- 说明
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human brain tissue were subjected to SDS PAGE followed by western blot with FNab09038(TSEN2 antibody) at dilution of 1:400
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze / thaw cycles.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))
- 别名
- TSEN2 (TSEN2 产品)
- 别名
- AU067695 antibody, RGD1309946 antibody, PCH2B antibody, SEN2 antibody, SEN2L antibody, tRNA splicing endonuclease subunit 2 antibody, TSEN2 antibody, Tsen2 antibody
- 背景
- Synonyms:HsSen2, PCH2B, SEN2, SEN2L, tRNA intron endonuclease Sen2, TSEN2 Background:Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'-and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
- 分子量
- 45kDa
- 基因ID
- 80746
- UniProt
- Q8NCE0
- 途径
- Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha
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