PPM1D 抗体 (C-Term)
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- 抗原 See all PPM1D 抗体
- PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PPM1D antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- 特异性
- PPM1D antibody is human, mouse and rat reactive. At least two isoforms of PPM1D are known to exist, this antibody will only detect the larger isoform.
- 纯化方法
- PPM1D antibody is affinity chromatography purified via peptide column.
- 免疫原
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PPM1D antibody was raised against an 18 amino acid peptide near the carboxy terminus of human PPM1D.
The immunogen is located within the last 50 amino acids of PPM1D. - 亚型
- IgG
- Top Product
- Discover our top product PPM1D Primary Antibody
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anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 201-300) antibody
PPM1D 适用: 人 WB, ELISA, IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 1-250) antibodyPPM1D 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 496-605) antibodyPPM1D 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D1 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (C-Term) antibodyPPM1D 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) antibodyPPM1D 适用: 人, 小鼠 WB, ELISA, IHC (p), ICC 宿主: 小鼠 Monoclonal 7E11-C5 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 571-602), (C-Term) antibodyPPM1D 适用: 人 WB 宿主: 兔 Polyclonal RB6018 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 183-212) antibodyPPM1D 适用: 人 WB 宿主: 兔 Polyclonal RB33957 unconjugated
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- 应用备注
- PPM1D antibody can be used for detection of PPM1D by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PPM1D antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- PPM1D antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- 抗原
- PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
- 别名
- PPM1D (PPM1D 产品)
- 别名
- PP2C-DELTA antibody, WIP1 antibody, AV338790 antibody, Wip1 antibody, zgc:103518 antibody, ppm1d antibody, wu:fj44c08 antibody, zgc:55836 antibody, zgc:77316 antibody, protein phosphatase, Mg2+/Mn2+ dependent 1D antibody, protein phosphatase 1D magnesium-dependent, delta isoform antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1D antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Db antibody, protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Da antibody, PPM1D antibody, Ppm1d antibody, ppm1db antibody, ppm1d.L antibody, ppm1da antibody
- 背景
- Wild-type p53 induced phosphatase 1 (WIP1) / protein phosphatase magnesium-dependent 1 delta (PPM1D), a protein identified in the p53 DNA response pathway, is a member of the PP2C family of serine/threonine protein phosphatases which selectively inactivates p38 MAPK and dephosphorylates the ATM/ATR targets, Chk1 and p53 (1,2). Studies have shown that it is overexpressed in human cancers and is involved in the regulation of multiple DNA damage signaling pathways (2,3). PPM1D deletion results in a reduction of T and B cell function and compromised cell division, rendering cells resistant to becoming cancerous and slowing tumor development (4,5).
- 分子量
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Predicted: 67 kDa
Observed: 68 kDa - 基因ID
- 8493
- NCBI登录号
- NP_003611
- UniProt
- Q8IVR6
- 途径
- p53 Pathway, Cell Division Cycle
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