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- 抗原 See all PPM1D 抗体
- PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
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抗原表位
- AA 183-212
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PPM1D antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- M
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the Central region of human PPM1D.
- 克隆位点
- RB33957
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PPM1D Primary Antibody
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anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 201-300) antibody
PPM1D 适用: 人 WB, ELISA, IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 1-250) antibodyPPM1D 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 496-605) antibodyPPM1D 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D1 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (C-Term) antibodyPPM1D 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) antibodyPPM1D 适用: 人, 小鼠 WB, ELISA, IHC (p), ICC 宿主: 小鼠 Monoclonal 7E11-C5 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 571-602), (C-Term) antibodyPPM1D 适用: 人 WB 宿主: 兔 Polyclonal RB6018 unconjugated
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- 应用备注
- WB: 1:1000. WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- PPM1D Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
- 有效期
- 6 months
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- 抗原
- PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
- 别名
- PPM1D (PPM1D 产品)
- 别名
- PP2C-DELTA antibody, WIP1 antibody, AV338790 antibody, Wip1 antibody, zgc:103518 antibody, ppm1d antibody, wu:fj44c08 antibody, zgc:55836 antibody, zgc:77316 antibody, protein phosphatase, Mg2+/Mn2+ dependent 1D antibody, protein phosphatase 1D magnesium-dependent, delta isoform antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1D antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Db antibody, protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Da antibody, PPM1D antibody, Ppm1d antibody, ppm1db antibody, ppm1d.L antibody, ppm1da antibody
- 背景
- The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
- 分子量
- 66675
- 基因ID
- 8493
- NCBI登录号
- NP_003611
- UniProt
- O15297
- 途径
- p53 Pathway, Cell Division Cycle
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