SHC1 抗体 (pTyr349)
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- 抗原 See all SHC1 抗体
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
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抗原表位
- pTyr349
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SHC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 特异性
- This antibody detects endogenous level of Shc1 only when phosphorylated at tyrosine 349.
- 纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
- 免疫原
- Shc1 (Phospho-Tyr349) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 349 (H-Q-Y (p) -Y-N) derived from Human Shc1.
- Top Product
- Discover our top product SHC1 Primary Antibody
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anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 171-280) antibody
SHC1 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 3F4 unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 385-495) antibodySHC1 适用: 人, 小鼠 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 2F7C7 unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 536-564), (C-Term) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 424-440), (C-Term) antibodySHC1 适用: 人, 大鼠 WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (C-Term) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 272-559) antibodySHC1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) antibodySHC1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (pTyr427) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (pTyr349) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 171-280) antibodySHC1 适用: 人 WB, IHC, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 3F4 unconjugated
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- 应用备注
- Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store antibody at -20°C for up to one year.
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- 抗原
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
- 别名
- Shc1 (SHC1 产品)
- 别名
- SHC1 antibody, SHC antibody, SHCA antibody, P66shc antibody, si:dkey-246i14.4 antibody, wu:fc10h03 antibody, shc antibody, p66shc antibody, Shc antibody, ShcA antibody, p66 antibody, SHC adaptor protein 1 antibody, Shc1p antibody, squalene--hopene cyclase antibody, SHC (Src homology 2 domain containing) transforming protein 1 antibody, SHC (Src homology 2 domain containing) transforming protein 1 L homeolog antibody, src homology 2 domain-containing transforming protein C1 antibody, SHC1 antibody, shc1 antibody, Shc1 antibody, shc1.L antibody
- 背景
- Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span
- 分子量
- 46, 52 kDa
- 基因ID
- 6464
- NCBI登录号
- NP_001123512
- UniProt
- P29353
- 途径
- RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
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