This antibody detects endogenous level of ASK1 only when phosphorylated at serine 966.
纯化方法
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
免疫原
ASK1 (Phospho-Ser966) antibody was raised against a peptide sequence around phosphorylation site of serine 966 (S-I-S (p) -L-P) derived from Human ASK1.
Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.