Mouse monoclonal antibody raised against native human HLA-DP/HLA-DR.
特异性
Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP and HLA-DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DP, DQ and DR, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
Flow Cytometry (0.5-1 μg/106 cells in 0.1 mL) Immunofluorescence (0.5-1 μg/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 μg/mL) The optimal working dilution should be determined by the end user.
限制
仅限研究用
状态
Liquid
缓冲液
In 10 mM PBS (0.05 % BSA, 0.05 % sodium azide).
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C
储存方法
Store at 4°C.
抗原
HLA-DPB1
(Major Histocompatibility Complex, Class II, DP beta 1 (HLA-DPB1))