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VEGFR2/CD309 抗体 (3rd Extracellular Domain)

Name: VEGFR2/CD309 抗体 (3rd Extracellular Domain)
SKU: ABIN5541982
Availability: OutOfStock

VEGFR2 适用: 人, Pig FACS, EIA 宿主: 大鼠 Monoclonal BEP-5D8 unconjugated

产品编号 ABIN5541982

发货至: 中国

Datasheet as PDF

抗原 See all VEGFR2/CD309 (VEGFR2) 抗体

VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
抗原表位
37

36

27

22

20

16

16

14

14

10

10

8

8

6

6

6

5

5

5

4

4

3

3

3

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
3rd Extracellular Domain
适用
299

196

145

18

8

7

4

3

3

3

2

1

1

1

1

1

1

1

1

1
人, Pig
宿主
302

48

8

2

1

1

1
大鼠
Compatible Secondaries
克隆类型
298

65
单克隆
标记
160

33

20

14

12

12

11

11

11

11

11

11

6

6

6

6

6

2

2

2

2

1

1

1

1

1

1

1

1
This VEGFR2/CD309 antibody is un-conjugated
应用范围
231

130

93

76

59

34

26

24

21

13

13

12

8

7

7

4

3

2

1
Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

特异性

This antibody detects VEGFR2 (epitope on the third extracellular immunoglobulin-like domain).

纯化方法

Protein G Chromatography

免疫原

genetic immunisation with cDNA encoding Human VEGFR2. Selection: based on recognition of the complete native protein expressed on transfected mammalian cells.

克隆位点

BEP-5D8

亚型

IgG2a

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应用备注

Flow Cytometry: 1.2 μg/10 6 cells. ELISA: 1/200-1/400. Cell based ELISA:

限制

仅限研究用
状态

Liquid

缓冲液

Phosphate buffered saline, pH 7.2

储存条件

4 °C,-20 °C

储存方法

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

有效期

12 months
抗原

VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

别名

cd309,vegfr-2,flk-1 (VEGFR2 产品)

别名

CD309 antibody, FLK1 antibody, VEGFR antibody, VEGFR2 antibody, 6130401C07 antibody, Flk-1 antibody, Flk1 antibody, Krd-1 antibody, Ly73 antibody, VEGFR-2 antibody, sVEGFR-2 antibody, Vegfr-2 antibody, FLK-1 antibody, flk-1 antibody, vegfr-2 antibody, KDR antibody, FLK/KDR antibody, flk1 antibody, flk1b antibody, kdrb antibody, si:busm1-205d10.1 antibody, si:ch211-254j6.1 antibody, si:ch211-278f21.4 antibody, wu:fc31a09 antibody, fk52c05 antibody, flk antibody, kdr antibody, kdra antibody, vegfr2 antibody, vegfr4 antibody, vegr2 antibody, wu:fk52c05 antibody, kinase insert domain receptor antibody, kinase insert domain protein receptor antibody, vascular endothelial growth factor receptor kdr-like antibody, kinase insert domain receptor (a type III receptor tyrosine kinase) antibody, kinase insert domain receptor like antibody, KDR antibody, Kdr antibody, LOC100136647 antibody, kdr antibody, kdrl antibody

背景

The vascular endothelial growth factor receptor-2 (VEGFR-2) plays an important role in the control of angiogenesis. This molecule is expressed on the surface of circulating endothelial stem cells as well as on adult vascular endothelial cells and other cell types (1). It is a 200- kDa type I transmembrane protein, consisting of a 19 amino acid leader peptide, a 744 amino acid extracellular domain made up of 7 immunoglobulin-like domains, a 24 amino acid transmembrane region and a 568 amino acid cytoplasmic domain. Interactions with VEGF ligands will stimulate angiogenesis, required in wound healing but also misused by tumours to promote their vascularization (2). The current monoclonal antibody was developed by genetic immunization against the complete extracellular domain of human VEGFR-2 and has been shown to be specific for the native target molecule and its counterpart in pigs using FACscan analyses on viable, transiently-transfected human BOSC23 cells (see Fig. 1). It binds to an epitope on the third extracellular immunoglobulin-like domain.

UniProt

P35968

途径

RTK signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling