MELK 抗体 (Middle Region)
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- 抗原 See all MELK 抗体
- MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
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抗原表位
- Middle Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MELK antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- MEETPKRKGA KVFGSLERGL DKVITVLTRS KRKGSARDGP RRLKLHYNVT
- 产品特性
- This is a rabbit polyclonal antibody against MELK. It was validated on Western Blot.
- 纯化方法
- Affinity purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of Human MELK
- Top Product
- Discover our top product MELK Primary Antibody
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anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 637-651) antibody
MELK 适用: 人 ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) antibodyMELK 适用: 人 ELISA, IHC, IF, FACS 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 637-651) antibodyMELK 适用: 人 ELISA, IHC, FACS, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 434-468), (C-Term) antibodyMELK 适用: 小鼠 WB, FACS 宿主: 兔 Polyclonal RB51204 unconjugated
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) antibodyMELK 适用: 人 IF, IHC (p), EIA 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (Center) antibodyMELK 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 101-250) antibodyMELK 适用: 人 ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) antibodyMELK 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 381-415) antibodyMELK 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51207 unconjugated
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (C-Term) antibodyVerified MELK 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
- 别名
- MELK (MELK 产品)
- 别名
- MELK antibody, xmelk antibody, Melk antibody, HPK38 antibody, AI327312 antibody, MPK38 antibody, mKIAA0175 antibody, fb71b01 antibody, fe01f04 antibody, wu:fb71b01 antibody, wu:fe01f04 antibody, maternal embryonic leucine zipper kinase antibody, maternal embryonic leucine zipper kinase L homeolog antibody, MELK antibody, melk antibody, cgd5_2270 antibody, Melk antibody, melk.L antibody
- 背景
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MELK is a serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. It acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. And it plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. It may also play a role in primitive hematopoiesis.
Alias Symbols: MELK, KIAA0175,
Protein Interaction Partner: UBC, YGR054W, Acaca, CSN1S1, MELK, MBP, LMNB1, BABAM1, ZNF622, SF3B1, EIF2S1, CDC5L, PPP1R8, HIST1H1B, CDC25B,
Protein Size: 457 - 基因ID
- 9833
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