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MELK 产品

(Maternal Embryonic Leucine Zipper Kinase (MELK))
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis.

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Featured MELK Categories

MELK 抗体

High quality antibodies with extensive validation data.

MELK ELISA试剂盒

Reliable ELISA kits for a wide range of species.

MELK 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MELK 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, ICC, FACS
Validations
  • (2)
  • (5)
Cat. No. ABIN969538
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF, FACS
Validations
  • (5)
Cat. No. ABIN1491623
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, FACS, IF/ICC
Validations
  • (6)
Cat. No. ABIN1844288
Quantity 100 μL
Datasheet Datasheet

Recommended MELK ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968452
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957656
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957654
Quantity 96 tests
Datasheet Datasheet

Recommended MELK 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (2)
Cat. No. ABIN5569684
Quantity 5 μg
Datasheet Datasheet
Reactivity Human
Source Insect cells (Sf9)
Validations
  • (2)
Cat. No. ABIN5569614
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310711
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our MELK Products

Li, Chen, Yang, Wang, Wang, Jin, Yang, Chen, Zhou, Luo: "Phillygenin, a MELK Inhibitor, Inhibits Cell Survival and Epithelial-Mesenchymal Transition in Pancreatic Cancer Cells." in: OncoTargets and therapy, Vol. 13, pp. 2833-2842, (2020) (PubMed).

Hu, Ru, Xiao, Chaturbedi, Hoa, Tian, Zhang, Ke, Yan, Nelson, Li, Gramer, Yu, Siegel, Zhang, Jia, Jadus, Limoli, Linskey, Xing, Zhou: "Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity." in: PLoS ONE, Vol. 8, Issue 11, pp. e80898, (2013) (PubMed).

Nakano, Joshi, Visnyei, Hu, Watanabe, Lam, Wexler, Saigusa, Nakamura, Laks, Mischel, Viapiano, Kornblum: "Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway." in: Neuro-oncology, Vol. 13, Issue 6, pp. 622-34, (2011) (PubMed).

Pickard, Green, Ellis, Caldas, Hedge, Mourtada-Maarabouni, Williams: "Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer." in: Breast cancer research : BCR, Vol. 11, Issue 4, pp. R60, (2009) (PubMed).

Lin, Park, Nishidate, Nakamura, Katagiri: "Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family." in: Breast cancer research : BCR, Vol. 9, Issue 1, pp. R17, (2007) (PubMed).

Niesler, Myburgh, Moore: "The changing AMPK expression profile in differentiating mouse skeletal muscle myoblast cells helps confer increasing resistance to apoptosis." in: Experimental physiology, Vol. 92, Issue 1, pp. 207-17, (2007) (PubMed).

Davezac, Baldin, Blot, Ducommun, Tassan: "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation." in: Oncogene, Vol. 21, Issue 50, pp. 7630-41, (2002) (PubMed).

Nagase, Seki, Ishikawa, Tanaka, Nomura: "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 3, Issue 1, pp. 17-24, (1996) (PubMed).

Synonyms and alternative names related to MELK

maternal embryonic leucine zipper kinase (MELK), maternal embryonic leucine zipper kinase (melk), maternal embryonic leucine zipper kinase (cgd5_2270), maternal embryonic leucine zipper kinase (Melk), maternal embryonic leucine zipper kinase L homeolog (melk.L), AI327312, fb71b01, fe01f04, HPK38, MELK, Melk, mKIAA0175, MPK38, wu:fb71b01, wu:fe01f04, xmelk

Protein level used designations for MELK

  • maternal embryonic leucine zipper kinase
  • maternal embryonic leucine zipper kinase-like
  • pEg3 kinase
  • protein kinase Eg3
  • protein kinase PK38
  • tyrosine-protein kinase MELK
  • zMelk
  • Protein kinase Eg3
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