Merlin 产品
(Neurofibromin 2 (NF2))
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This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development\; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008].
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Featured Merlin Categories
Merlin 抗体
High quality antibodies with extensive validation data.
Merlin ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Merlin 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Merlin 抗体
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Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IP
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- (6)
Cat. No.
ABIN6144548
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
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- (3)
Cat. No.
ABIN7434395
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7441928
Quantity
100 μL
Datasheet
Datasheet
Recommended Merlin ELISA试剂盒
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Reactivity
Analytical Method
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Cat. No.
Quantity
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Reactivity
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Analytical Method
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- (1)
Cat. No.
ABIN6968860
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Quantitative Sandwich ELISA
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- (1)
Cat. No.
ABIN6958099
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380639
Quantity
2 x 96 tests
Datasheet
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Recommended Merlin 蛋白
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Reactivity
Source
Validations
Cat. No.
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Datasheet
Reactivity
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Source
Wheat germ
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Cat. No.
ABIN1312430
Quantity
10 μg
Datasheet
Datasheet
Reactivity
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Source
Tobacco (Nicotiana tabacum)
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Cat. No.
ABIN3134109
Quantity
1 mg
Datasheet
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Reactivity
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Escherichia coli (E. coli)
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ABIN7504952
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Latest Publications for our Merlin Products
: "An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice." in: Cell stem cell, Vol. 21, Issue 1, pp. 91-106.e6, (2018) (PubMed).: "Influence of Membrane Receptor Lateral Diffusion on the Short-Term Depression of Acetylcholine-Induced Current in Helix Neurons." in: Cellular and molecular neurobiology, (2017) (PubMed).
: "Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP." in: Genes & development, Vol. 29, Issue 12, pp. 1285-97, (2015) (PubMed).
: "Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators." in: Development (Cambridge, England), Vol. 140, Issue 16, pp. 3323-34, (2013) (PubMed).
: "Cellular expression profile for interstitial cells of cajal in bladder - a cell often misidentified as myocyte or myofibroblast." in: PLoS ONE, Vol. 7, Issue 11, pp. e48897, (2012) (PubMed).
: "Expression of P2X7 receptor increases in vivo tumor growth." in: Cancer research, Vol. 72, Issue 12, pp. 2957-69, (2012) (PubMed).
: "Combining Curcumin (Diferuloylmethane) and Heat Shock Protein Inhibition for Neurofibromatosis 2 Treatment: Analysis of Response and Resistance Pathways." in: Molecular cancer therapeutics, (2011) (PubMed).
: "The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals." in: Developmental cell, Vol. 19, Issue 1, pp. 27-38, (2010) (PubMed).
: "Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cells." in: Journal of cell science, Vol. 122, Issue Pt 22, pp. 4141-9, (2010) (PubMed).
: "The phosphorylation status of merlin in sporadic vestibular Schwannomas." in: Molecular and cellular biochemistry, Vol. 324, Issue 1-2, pp. 201-6, (2009) (PubMed).
Synonyms and alternative names related to Merlin
neurofibromin 2 (NF2), neurofibromin 2 (Nf2), neurofibromin 2a (merlin) (nf2a), neurofibromin 2b (merlin) (nf2b), neurofibromin 2 (merlin) S homeolog (nf2.S), ACN, BANF, merlin, NF2, nf2, NF2a, SCH, zgc:194620, zgc:194631Protein level used designations for Merlin
- merlin
- moesin-ezrin-radixin like
- moesin-ezrin-radixin-like protein
- moesin-ezrin-radizin-like protein
- neurofibromin 2 (bilateral acoustic neuroma)
- neurofibromin-2
- schwannomerlin
- schwannomin
- neurofibromin 2
- neurofibromatosis 2
- LOW QUALITY PROTEIN: merlin
- neurofibromin 2 (merlin) S homeolog
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