SOX10 抗体 (AA 115-269)
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- 抗原 See all SOX10 抗体
- SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
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抗原表位
- AA 115-269
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SOX10 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- Protein G Chromatography
- 免疫原
- A partial length recombinant SOX-10 protein (amino acids 115-269) was used as the immunogen for this antibody.
- 克隆位点
- ABM4E24
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product SOX10 Primary Antibody
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anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibody
SOX10 适用: 人, 小鼠 WB, IHC, StM 宿主: 小鼠 Monoclonal SOX10-991 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (Middle Region) antibodySOX10 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 147-252) antibodySOX10 适用: 人 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 2E7B5 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 147-252) antibodySOX10 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 2E7E8 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 231-259) antibodySOX10 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB21835 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibodySOX10 适用: 人, 小鼠 IHC, StM 宿主: 兔 Monoclonal SOX10-2311R unconjugated Recombinant Antibody
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibodySOX10 适用: 人, 小鼠 IHC, StM 宿主: 小鼠 Monoclonal rSOX10-1074 unconjugated Recombinant Antibody
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibodySOX10 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal SOX10-992 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 200-300) antibodySOX10 适用: 人 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 231-259) antibodySOX10 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 2-4 μg/mL
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- PBS containing 0.05 % BSA, PH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- 抗原
- SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
- 别名
- SOX10 (SOX10 产品)
- 别名
- DOM antibody, PCWH antibody, WS2E antibody, WS4 antibody, WS4C antibody, SOX-10 antibody, SOX10 antibody, dom antibody, ws4 antibody, Dom antibody, Sox21 antibody, SOX9 antibody, cls/sox10 antibody, zgc:100757 antibody, SRY-box 10 antibody, SRY box 10 antibody, SRY-box 10 L homeolog antibody, SRY (sex determining region Y)-box 10 antibody, SOX10 antibody, Sox10 antibody, sox10.L antibody, sox10 antibody
- 背景
- SOX10 is a transcription factor that belongs to the high mobility group (HMG) box super family of DNA-binding proteins. It is located at 22q13.1 and is highly conserved in vertebrates. SOX10 is expressed in many different cell types and tissues and implicated in neural crest development, nervous system neurogenesis, as well as differentiation of oligodendrocyte, glia and melanocytes. It modulates other transcription factors including PAX3 forming a complex and acts as a nucleocytoplasmic shuttle protein in neural crest and oligodendrocyte development. The level of expression of SOX10 plays pivotal regulatory role both in tumor progression and suppression. Its elevated expression, possess tumor-promoting activities in several malignancies including melanoma and gliomas. Decreased expression of SOX10 promotes tumor cell growth and focal adhesions of Merlin-null schwannoma cells. SOX10 may also function as a tumor suppressor by inducing tumor cell apoptosis, inhibiting invasion, regulating cell EMT and stemness through suppressing Wnt/Beta-catenin signaling. Mutations of the Sox10 gene are known to cause various combinations of hearing loss and pigmentation defects in humans such as Waardenburg syndrome, a rare auditory-pigmentary disorder that generates varying combinations of hearing loss and pigmentation defects.
- 分子量
- 50 kDa
- 基因ID
- 6663
- UniProt
- P56693
- 途径
- Chromatin Binding
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