S1PR1 抗体 (AA 86-382)
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- 抗原 See all S1PR1 抗体
- S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))
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抗原表位
- AA 86-382
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This S1PR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- Protein A Chromatography
- 免疫原
- A partial length recombinant Edg-1 protein (amino acids 86-382) was used as the immunogen for this antibody.
- 亚型
- IgG
- Top Product
- Discover our top product S1PR1 Primary Antibody
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anti-Sphingosine-1-Phosphate Receptor 1 (S1PR1) (C-Term) antibody
S1PR1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 1 (S1PR1) (AA 51-150) antibodyS1PR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 1 (S1PR1) (AA 311-382) antibodyS1PR1 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 1 (S1PR1) (AA 1-47) antibodyS1PR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E12 unconjugated
anti-Sphingosine-1-Phosphate Receptor 1 (S1PR1) antibodyS1PR1 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 1E3H5 unconjugated
anti-Sphingosine-1-Phosphate Receptor 1 (S1PR1) (AA 1-47) antibodyS1PR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F11 unconjugated
anti-Sphingosine-1-Phosphate Receptor 1 (S1PR1) (Internal Region) antibodyS1PR1 适用: 人, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 1 (S1PR1) (Ser311) antibodyS1PR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 1 (S1PR1) (AA 1-382) antibodyS1PR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 1 (S1PR1) (AA 17-30), (Extracellular), (N-Term) antibodyS1PR1 适用: 人, 小鼠, 大鼠 WB, IF, IHC, ICC, LCI 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 2-4 μg/mL
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- PBS containing 0.05 % BSA, PH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- 抗原
- S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))
- 别名
- SIP1 receptor/Edg-1 (S1PR1 产品)
- 别名
- CD363 antibody, CHEDG1 antibody, D1S3362 antibody, ECGF1 antibody, EDG-1 antibody, EDG1 antibody, S1P1 antibody, AI849002 antibody, Edg1 antibody, Lpb1 antibody, S1p antibody, S1p1 antibody, S1P receptor 1 antibody, S1P receptor Edg-1 antibody, edg1 antibody, etID43307.22 antibody, s1p1 antibody, wu:fb98f05 antibody, s1pr1 antibody, xts1p1 antibody, sphingosine-1-phosphate receptor 1 antibody, sphingosine-1-phosphate receptor 1 L homeolog antibody, S1PR1 antibody, S1pr1 antibody, s1pr1 antibody, s1pr1.L antibody
- 背景
- S1PR1 (Sphingosine-1-phosphate receptor 1) is a G-protein coupled receptor, which binds the bioactive S1P (sphingolipid, sphingosine-1-phosphate) as a high affinity ligand. S1P is present at high levels in blood and lymph, and plays a critical role in the homeostasis of the vascular and immune systems. S1PR1 was originally identified as an abundant transcript in endothelial cells and plays a key role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In the immune system, S1PR1 signaling is important in the regulation of lymphocyte migration and trafficking. Inhibition of S1PR1 results in lymphocyte sequestration within lymphoid organs. S1PR1 may also regulate tumor cell functions in some types of B cell lymphoma. Inhibition of S1PR1 expression down regulates signal transducer and activator of transcription 3 activity, leading to inhibition of lymphoma tumor cell growth. S1PR1 signaling in T cells drives Treg accumulation in tumors, limits CD8+ T cell recruitment and activation, and promotes tumor growth.
- 分子量
- 42 kDa
- 基因ID
- 1901
- UniProt
- P21453
- 途径
- Signaling Events mediated by VEGFR1 and VEGFR2
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