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FAK 抗体 (pTyr925)

Name: FAK 抗体 (pTyr925)
SKU: ABIN498708
Availability: OutOfStock

PTK2 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Western blot (WB) analyzes of p-FAK antibody in extracts from HepG2 cells. (FAK 抗体 (pTyr925))

Immunhistochemistry (IHC) analuyes of FAK antibody in paraffin-embedded human brain tissue. (FAK 抗体 (pTyr925))

IHC (p)

2 images

产品编号 ABIN498708

发货至: 中国

Datasheet as PDF

抗原 See all FAK (PTK2) 抗体

FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
抗原表位
35

29

27

24

23

23

18

18

16

16

12

11

8

7

6

6

5

5

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
pTyr925
适用
318

280

217

21

21

17

16

11

8

6

6

4

3

3

2

1

1

1

1

1
人, 小鼠, 大鼠
宿主
330

17

3

2

1

1
兔
Compatible Secondaries
克隆类型
324

30
多克隆
标记
170

19

16

13

13

13

13

13

13

13

10

9

9

9

9

9

2

1
This FAK antibody is un-conjugated
应用范围
293

125

122

121

107

70

68

49

31

27

22

5

2

2
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

特异性

This antibody detects endogenous levels of FAK protein only when phosphorylated at Tyr925.

交叉反应（详细）

Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

纯化方法

Affinity chromatography

纯度

> 95 % by SDS-PAGE

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应用备注

Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

1,0 mg/mL

缓冲液

Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
抗原

FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

别名

FAK1 / PTK2 (PTK2 产品)

别名

FADK antibody, FAK antibody, FAK1 antibody, FRNK antibody, PPP1R71 antibody, p125FAK antibody, pp125FAK antibody, PTK2 antibody, Fadk antibody, mKIAA4203 antibody, fak antibody, fak1a antibody, ptk2 antibody, ptk2a antibody, wu:fa18c04 antibody, zgc:66114 antibody, CG10023 antibody, CT28129 antibody, DFAK antibody, DFak antibody, DFak56 antibody, Dfak antibody, Dfak56 antibody, DmFAK antibody, Dmel\\CG10023 antibody, Fak56 antibody, Fak56D antibody, fak56 antibody, protein tyrosine kinase 2 antibody, protein tyrosine kinase 2 L homeolog antibody, PTK2 protein tyrosine kinase 2 antibody, protein tyrosine kinase 2ab antibody, Focal adhesion kinase antibody, PTK2 antibody, ptk2.L antibody, Ptk2 antibody, ptk2ab antibody, Fak antibody

背景

Activation of integrins in the extracellular matrix (ECM) of eukaryotic cells promotes the formation of membrane adhesion complexes, known as focal adhesions, which can include cytoskeletal proteins and protein tyrosine kinases, such as focal adhesion kinase (FAK). Phosphorylation events occurring within focal adhesions influence numerous processes that include mitogenic signaling, cell survival and cell motility. FAK is a non-receptor tyrosine kinase that is ubiquitously expressed and highly conserved between species. FAK is recruited by integrin clusters and variably phosphorylated depending on the effector molecules present in the focal adhesion. Phosphorylation of FAK Tyr 397 decreases during serum starvation, contact inhibition and cell cycle arrest, all conditions under which activating FAK Tyr 407 phosphorylation increases.Synonyms: FADK1, FAK, Focal adhesion kinase 1, Protein-tyrosine kinase 2, pp125FAK

分子量

approx. 125 kDa

基因ID

5747

NCBI登录号

NP_005598

UniProt

Q05397

途径

Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling