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- 抗原 See all DAB1 抗体
- DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DAB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 特异性
- This antibody detects endogenous levels of Dab1 protein. (region surrounding Gln226)
- 交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity chromatography
- 纯度
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product DAB1 Primary Antibody
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anti-Disabled Homolog 1 (Drosophila) (DAB1) (pTyr232) antibody
DAB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (AA 400-555), (C-Term) antibodyDAB1 适用: 小鼠, 兔 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (AA 400-555), (C-Term) antibodyDAB1 适用: 小鼠 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (pTyr232) antibodyDAB1 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (Ser296) antibodyDAB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (AA 1-185) antibodyDAB1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (pTyr198) antibodyDAB1 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) antibodyDAB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (Ser295) antibodyDAB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (AA 187-236) antibodyDAB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western Blot: 1/500 - 1/1000. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1,0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))
- 别名
- DAB1 (DAB1 产品)
- 别名
- AI956902 antibody, C630028C02Rik antibody, scm antibody, scr antibody, scrambler antibody, yot antibody, disabled-1 antibody, LOC100232823 antibody, si:dkey-242m13.1 antibody, DAB1 antibody, zgc:136547 antibody, DAB1, reelin adaptor protein antibody, disabled 1 antibody, disabled homolog 1 antibody, Dab, reelin signal transducer, homolog 1a (Drosophila) antibody, Dab, reelin signal transducer, homolog 1b (Drosophila) antibody, DAB1 antibody, Dab1 antibody, LOC100232823 antibody, dab1a antibody, dab1b antibody
- 背景
- Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl. Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants. Reelin is a secreted protein thought to play a role in directing migrating neurons. Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain. Dab2 (also designated DOC-2) is a mitogen-responsive phosphoprotein that binds the SH3 domain of Grb2, and it is thought to be a negative regulator of growth.Synonyms: Disabled homolog 1
- 分子量
- approx. 60 kDa
- 基因ID
- 1600
- NCBI登录号
- NP_066566
- UniProt
- O75553
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