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- 抗原 See all Nephrin (NPHS1) 抗体
- Nephrin (NPHS1) (Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Nephrin antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of Nephrin protein. (region surrounding His892)
- 交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity chromatography
- 纯度
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product NPHS1 Primary Antibody
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anti-Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) (AA 23-92) antibody
NPHS1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) (AA 451-550) antibodyNPHS1 适用: 人, 小鼠, 大鼠, 犬 FACS 宿主: 兔 Polyclonal unconjugated
anti-Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) (AA 27-234) antibodyNPHS1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) (AA 27-234) antibodyNPHS1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C8 unconjugated
anti-Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) (AA 23-257) antibodyNPHS1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) (AA 1191-1219), (Tyr1210) antibodyNPHS1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB28264 unconjugated
anti-Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) (C-Term) antibodyNPHS1 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) (AA 39-144) antibodyNPHS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) (AA 39-106) antibodyNPHS1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) (AA 33-122) antibodyNPHS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D2 unconjugated
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- 应用备注
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Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1,0 mg/mL
- 缓冲液
- PBS, pH ~7.2, 0.05 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- Nephrin (NPHS1) (Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1))
- 别名
- Nephrin (NPHS1 产品)
- 别名
- NPHS1 antibody, nphs1l antibody, nphs1 antibody, CNF antibody, NPHN antibody, nephrin antibody, NephrinB antibody, NPHS1, nephrin antibody, nephrosis 1, congenital, Finnish type (nephrin) antibody, NPHS1 nephrin S homeolog antibody, nephrin antibody, NPHS1 nephrin antibody, nephrosis 1, nephrin antibody, NPHS1 antibody, nphs1 antibody, nphs1.S antibody, LOC5579127 antibody, Nphs1 antibody
- 背景
- Nephrin is a member of the immunoglobulin family of cell adhesion molecules that localizes to opposing sites of the secondary foot processes formed by podocytes, a specialized epithelial cell that ensures size- and charge-selective ultrafiltration. The human nephrin gene maps to chromosome 19q13.1 and encodes a 1,241 amino acid protein that contains a transmembrane domain, 8 Ig-like modules, and 1 fibronectin III-like module. Nephrin is expressed in embryonic and adult kidneys and localizes to glomerular podocytes and the glomerular slit diaphragm. Nephrin stimulates mitogen-activated protein kinases and is enhanced by podocin, which binds to the cytoplasmic tail of nephrin. A293 cells treated with Phorbol-12-myristate- 13-acetate can upregulate nephrin, suggesting that protein kinase C is part of an intracellular signalling system, which regulates nephrin. Nephrin identified in mouse glomerular extract is a protein with an apparent molecular mass of 185 kDa.Synonyms: NPHN, NPHS1
- 分子量
- approx. 135 kDa
- 基因ID
- 4868
- NCBI登录号
- NP_004637
- UniProt
- O60500
- 途径
- Regulation of Actin Filament Polymerization, Skeletal Muscle Fiber Development
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