Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
WWOX (WW domain containing oxidoreductase) protein is a candidate tumor suppressor consisting of two WW domains that influence protein-protein interactions, and a short chain dehydrogenase (SDR) domain, that influences sex-steroid metabolism. Modulation of the WWOX gene influences esophageal squamous cell carcinogenesis and tumorigenicity of breast cancer cell lines MDA-MB-435 and T47D. The murine homolog WOX1 localizes in the mitochondri,a and contains a mitochondrial targeting sequence mapping within the SDR domain. JNK1 can physically associate with WOX1 and sequester WOX1-dependent apoptosis.Synonyms: FOR I, FOR II, FOR III, FOR IV, FOR1, FOR2, FOR3, Fragile site FRA16D oxidoreductase, WOX1, WOX2, WOX3, WW domain-containing oxidoreductase, WWOXdelta5-8, WWOXdelta6-8, WWOXv1, WWOXv2, WWOXv3, WWOXv4, WWOXv8