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HLA-A 抗体 (AA 70-99)

HLA-A 适用: 小鼠 WB, ELISA 宿主: 小鼠 Monoclonal 7G7F9 unconjugated
产品编号 ABIN3031678
发货至: 中国
  • 抗原 See all HLA-A 抗体
    HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))
    抗原表位
    • 9
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 70-99
    适用
    • 66
    • 14
    • 6
    • 3
    • 1
    小鼠
    宿主
    • 39
    • 33
    • 3
    小鼠
    克隆类型
    • 41
    • 34
    单克隆
    标记
    • 42
    • 7
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HLA-A antibody is un-conjugated
    应用范围
    • 44
    • 36
    • 28
    • 21
    • 19
    • 11
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    交叉反应 (详细)
    Expected species reactivity: Human
    纯化方法
    Purified
    免疫原
    A portion of amino acids 70-99 from the human protein was used as the immunogen for this HLA-A antibody.
    克隆位点
    7G7F9
    亚型
    IgG1
    Top Product
    Discover our top product HLA-A Primary Antibody
  • 应用备注
    Titration of the HLA-A antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:250
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Aliquot the HLA-A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原
    HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))
    别名
    HLA-A (HLA-A 产品)
    别名
    HLAA antibody, major histocompatibility complex, class I, A antibody, HLA-A antibody
    背景
    HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
    UniProt
    P04439
    途径
    TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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