HLA-DRB1 抗体
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- 抗原 See all HLA-DRB1 抗体
- HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
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适用
- 人, 猴
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This HLA-DRB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Protein G affinity chromatography
- 免疫原
- Activated human peripheral blood mononuclear cells were used as the immunogen for the HLA-DRB1 antibody.
- 克隆位点
- HLA-DRB-1067
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product HLA-DRB1 Primary Antibody
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anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-266) antibody
HLA-DRB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人, 猴 WB, FACS, IF, IHC, ISt, StM 宿主: 小鼠 Monoclonal LN-3 unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 27-264) antibodyHLA-DRB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 WB, IF, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 1-266) antibodyHLA-DRB1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 IHC 宿主: 兔 Monoclonal MSVA-478R unconjugated Recombinant Antibody
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-58) antibodyHLA-DRB1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21019 unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 30-266) antibodyHLA-DRB1 适用: 人 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) (AA 31-266) antibody (Biotin)HLA-DRB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal Biotin
anti-Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1) antibodyHLA-DRB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Optimal dilution of the HLA-DRB1 antibody should be determined by the researcher.
1. Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 0.25-0.5 μg/mL for 30 min at RT (1),Prediluted format : incubate for 30 min at RT (2) - 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
- 储存液
- Azide free
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store the HLA-DRB1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- 抗原
- HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
- 别名
- HLA-DRB1 (MHC II) (HLA-DRB1 产品)
- 别名
- MGC108235 antibody, DRB1 antibody, DRw10 antibody, HLA-DR1B antibody, HLA-DRB antibody, SS1 antibody, major histocompatibility complex, class II, DR beta 1 antibody, hla-drb1 antibody, HLA-DRB1 antibody
- 背景
- This mAb reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. Its epitope is different from that of mAb L243. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
- 途径
- TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Cancer Immune Checkpoints
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